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DOI: 10.1055/s-0043-1772604
Diffuse leptomeningeal enhancement in neurosarcoidosis-related longitudinally extensive myelitis
Realce leptomeníngeo difuso na mielite longitudinalmente extensa relacionada à neurossarcoidoseA 35-year-old man presented with a 1-month history of bilateral lower limb weakness and numbness. On examination, he had paraparesis with lower limbs hyperreflexia, and T5 sensory level. Magnetic resonance imaging (MRI) of the spine revealed a longitudinally extensive myelitis (LETM) with a diffuse leptomeningeal enhancement ([Figure 1]). Thorax computed tomography (CT) disclosed bilateral hilar lymphadenopathy. A transbronchial lymph node fine-needle biopsy revealed noncaseating granulomas. Considering this finding, probable neurosarcoidosis was diagnosed.
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Leptomeningeal involvement is a remarkable finding in neurosarcoidosis.[1] When central nervous system (CNS) involvement occurs concomitantly with a widespread leptomeningeal enhancement, sarcoidosis should be considered as a possible differential diagnosis.[2]
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Conflict of Interest
The authors have no conflict of interest to declare.
Authors' Contributions
FFA, MPMM: conceptualization, writing – original draft, writing – review & editing; JLP, OGB: conceptualization, writing – review & editing.
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References
- 1 Murphy OC, Salazar-Camelo A, Jimenez JA. et al. Clinical and MRI phenotypes of sarcoidosis-associated myelopathy. Neurology(R) neuroimmunology & neuroinflammation. NLM (Medline); 2020: 7
- 2 Dutra LA, Braga-Neto P, Oliveira RA, Pedroso JL, Abrahão A, Barsottini OGP. Neurosarcoidosis: guidance for the general neurologist. Arq Neuropsiquiatr 2012; 70 (04) 293-299 . DOI: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000400014&lng=en&tlng=en [online serial]
Address for correspondence
Publikationsverlauf
Eingereicht: 18. April 2023
Angenommen: 03. Mai 2023
Artikel online veröffentlicht:
13. Oktober 2023
© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)
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References
- 1 Murphy OC, Salazar-Camelo A, Jimenez JA. et al. Clinical and MRI phenotypes of sarcoidosis-associated myelopathy. Neurology(R) neuroimmunology & neuroinflammation. NLM (Medline); 2020: 7
- 2 Dutra LA, Braga-Neto P, Oliveira RA, Pedroso JL, Abrahão A, Barsottini OGP. Neurosarcoidosis: guidance for the general neurologist. Arq Neuropsiquiatr 2012; 70 (04) 293-299 . DOI: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000400014&lng=en&tlng=en [online serial]
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