Highly Efficient and Practical Oxidative Bromination of Electron-Rich Arenes Using S-Methyl Methanethiosulfonate as the Oxidant

Abstract

An efficient and practical method for the bromination of electron-rich arenes and heteroarenes was developed by using S-methyl methanethiosulfonate as the oxidant. All the bromine atoms were basically transferred to the brominated products, demonstrating the exceptional atom economy and practicality of the proposed protocol. The method reduces the amount of bromine required for this reaction system and obtains products in moderate to good yields.

Key words

bromination - aromatic ring - S-methyl methanethiosulfonate - regioselective - oxidation

Publication History

Received: 22 December 2023

Accepted after revision: 04 April 2024

Article published online:
26 April 2024

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