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Klin Monbl Augenheilkd 2019; 236(02): 192-194
DOI: 10.1055/s-0043-112858
DOI: 10.1055/s-0043-112858
Der interessante Fall
Therapie des fortgeschrittenen Basalzellkarzinoms mittels Hedgehog-Inhibition
Therapy of Advanced Basal Cell Carcinoma by Hedgehog InhibitionFurther Information
Publication History
eingereicht 12 January 2017
akzeptiert 22 May 2017
Publication Date:
01 August 2017 (online)
![](https://www.thieme-connect.de/media/klimo/201902/lookinside/thumbnails/10-1055-s-0043-112858_klm1727-1.jpg)
Anamnese, Befunde
Ein 79-jähriger männlicher Patient stellte sich in unserer Augenklinik bei massiver Tumorinfiltration eines Basalzellkarzinoms beider Augenlider, rechts mehr als links (siehe [Abb. 1]), vor. Anamnestisch erfolgte bereits 2005 und 2009 am rechten Auge eine Basalzellkarzinomexzision. Seit 2009 seien keine weiteren augenärztlichen Vorstellungen erfolgt.
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Literatur
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- 2 Bale AE, Yu KP. The hedgehog pathway and basal cell carcinomas. Hum Mol Genet 2001; 10: 757-762
- 3 Hutchin ME, Kariapper MS, Grachtchouk M. et al. Sustained hedgehog signaling is required for basal cell carcinoma proliferation and survival: conditional skin tumorigenesis recapitulates the hair growth cycle. Genes Dev 2005; 19: 214-223
- 4 Teh MT, Blaydon D, Chaplin T. et al. Genomewide single nucleotide polymorphism microarray mapping in basal cell carcinomas unveils uniparental disomy as a key somatic event. Cancer Res 2005; 65: 8597-8603
- 5 Scales SJ, de Sauvage FJ. Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol Sci 2009; 30: 303-312
- 6 Kakkassery V, Loeffler KU, Sand M. et al. Current diagnostics and therapy recommendations for ocular basal cell carcinoma. Ophthalmologe 2017; 114: 224-236
- 7 Sekulic A, Mangold AR, Northfelt DW. et al. Advanced basal cell carcinoma of the skin: targeting the hedgehog pathway. Curr Opin Oncol 2013; 25: 218-223
- 8 Papastefanou VP, René C. Secondary resistance to vismodegib after initial successful treatment of extensive recurrent periocular basal cell carcinoma with orbital invasion. Ophthal Plast Reconstr Surg 2017; 33 (3S Suppl 1): S68-S70