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DOI: 10.1055/s-0042-1751875
Expanded [23]-Helicene
Expanded [23]-Helicene with Exceptional Chiroptical Properties via an Iterative Ring-Fusion Strategy.
J. Am. Chem. Soc. 2022;
144: 23421-23427
DOI: 10.1021/jacs.2c09555.
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Significance
Large helical structures are unique and sometimes irreplaceable molecular scaffolds serving special functions. By combining linear and angular ring-fusion modules, a set of expanded helicenes are designed and synthesized via convenient procedures, demonstrating extraordinary chiroptical properties reaching into the visible range.
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Comment
The key step to attaining the large helicenes first requires the assembly of polyaryl precursors comprising one or more 2,2′-diethynylbiphenyl moieties. Then, iridium- or rhodium-catalyzed [2+2+2] reactions are performed to accomplish helicenes composed of 15, 19, and 23 rings in the circuit.
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Publikationsverlauf
Artikel online veröffentlicht:
14. April 2023
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