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DOI: 10.1055/s-0042-1742577
Sedation and General Anesthesia in Diagnostic Pediatric Imaging
- Abstract
- Introduction
- History and Literature
- Definition of Sedation
- Adverse Effects and Complications to Sedation and General Anesthesia
- Sedation and General Anesthesia—Personnel
- Equipment and Monitoring
- Special Problems due to Imaging Modality for Sedation/GA
- Sedation and General Anesthesia Drugs
- Most Used Medications
- Summary
- References
Abstract
Objective In this article we will try and provide a comprehensive literature review on the use of sedation and general anesthesia (SAGA) in pediatric population for diagnostic studies and the salient differences in practices worldwide particularly with regards to the practice differences in developed versus developing countries.
Methods The key articles we obtained were primarily from Indian Journal of Anesthesia, Local NHS Trust protocols, PubMed, MEDLINE, NICE Evidence, UptoDate (Wolters Kluwer), and The Cochrane Library.
Results In the last two decades pediatric radiology has seen a huge increase in volume of procedures with a proportional increase in SAGA. The duration being dependent on the modality (for example, few minutes for computed tomography scan and up to an hour for magnetic resonance imaging particularly if there are multiple studies). SAGA has an extensive list of adverse effects that could be due to the underlying drug or due to wrong patient selection. The principles for safe use of the drugs remain the same just like any other medical or surgical procedure and include meticulous assessments of children and ruling out the contraindications, obtaining parental consent, deciding the drugs which can be given, ascertain the duration of procedure after communication with the radiologist, monitor closely before, during, and after the procedure, discharge, and after the discharge criteria are met. All the above criteria depend on the local guidelines and therefore vary from not only one country to the other but also from one institution to the other within the same country.
Conclusion As expected, the SAGA techniques, drugs, and personnel involved in delivering the care vary from country to country. However, the final and desired outcome remains the same that is to deliver safe care with acquisition of optimal images that serve the purpose of arriving at the correct diagnosis.
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Introduction
The two main aims of sedation and general anesthesia (SAGA) are control of anxiety and prevention of movement to acquire optimal images with no motion artifacts. Another reason for sedation/GA could also be wishes of the parents if they do not want the child to remember the experience. The American Academy of Pediatrics (AAP) defines the goals of sedation in the pediatric patient for diagnostic and therapeutic procedures as follows: to guard the patient's safety and welfare; to minimize physical discomfort and pain; to control anxiety, minimize psychological trauma, and maximize the potential for amnesia; to control behavior and/or movement to allow for the safe completion of the diagnostic/interventional procedure; and to return the patient to a state from which safe discharge is possible.[1] The drugs used for SAGA will depend on the imaging modality, number of studies involved, and the patient characteristics. Therefore, a short procedure like computed tomography (CT) might not require GA but on the other hand magnetic resonance imaging (MRI) that can take anywhere between 10 minutes to an hour depending on the study usually requires deep sedation or GA. MRI can be particularly frightening because it is noisy, has relatively long scan time, and involves lying still in an enclosed space, therefore waking up in the middle of the procedure can be a disturbing experience.
The rate of failure of adequate image acquisition has been reported to be as low as 1 to 3% in some studies,[2] and even frequent as 10 to 20% in others.[3] [4] Worldwide there has been a shift toward administering drugs according to predefined protocol and studies have suggested that this decreases the failure rate.[5] Studies have shown that the procedures were more likely to be successful in children who were imaged under GA like the ones by Malviya et al[6] which reported a clear improvement in the quality of MRI scans performed using GA compared with those using moderate sedation. It is essential to minimize the risk of procedure failure due to patient movement and rescheduling as it is a major burden on patient and family who must come again as well as for the radiology team in terms of time loss and arranging a new appointment in busy department. It is better to assess the patients prior to the procedure, decide the strategy (sedation vs. GA), and employ the appropriate technique only. Sedation has long been used for clear image acquisition and was provided by the radiological staff only, particularly in developing countries. However, in recent years especially due to rising legal issues there has been a trend toward employing and using dedicated services of individuals or personnel who have the expertise in delivering SAGA in pediatric population. The monitoring and the qualification of the individual/team depends on the local hospital/prevalent guidelines and may include dedicated trained nurses, pediatricians, emergency physicians, and/or anesthesiologists.
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History and Literature
Until 1985 there were no guidelines for pediatric sedation. Unfortunate adverse events in dental offices heightened awareness of the hazards of pediatric sedation. This led the AAP to develop guidelines for the elective use of SAGA by Dr. Charles Coté and Dr. Theodore Striker.[7] In 1992, the AAP Committee on Drugs revised the 1985 guidelines. It was acknowledged that a deeper unintended level of sedation could be easily reached. Pulse oximetry was recommended for all patients undergoing sedation.[8] “The guidelines underwent subsequent revision by the AAP in 1998, 2002, and 2006” (“BIR Publications”). During the following years, the American Association of Anesthesiologists (ASA) became involved with the sedation safety, in part because the Joint Commission on Accreditation of HealthCare Organizations (JCAHO) modified their regulations in such a way that made departments of anesthesiology responsible for developing “within-institution” sedation guidelines. The first ASA iteration succeeded in changing the terminology from the oxymoron “conscious sedation” to the more appropriate term “sedation/analgesia.” In 2002, the ASA published revised sedation guidelines that address all depths of sedation.[5] The ASA, working closely with JCAHO, also developed new language to describe the sedation's process, which was later incorporated by the JCAHO.
Now, besides GA, three stages of sedation are described—minimal sedation, moderate sedation, and deep sedation. Recently, the AAP adopted the ASA definitions for their sedation guidelines (“Discharge Criteria for Children Sedated by …”). The Neuroanesthesia and Neurointensive Study Group of the Italian Society of Anesthesia, Analgesia, Resuscitation, and Intensive Care (SIAARTI) with the Italian Society of Neonatal and Pediatric Anesthesia and Resuscitation (SARNePI) have been published in 2004—the SIAARTI-SARNePI Guidelines—for sedation in pediatric neuroradiology.[9]
However, all these studies and guidelines failed to ensure a standard set of terminology to define the relevant procedures involved in sedation and the adverse effects due to SAGA. Standardization of recommendations was required to safeguard against confusion and untoward events (“BIR Publications”). The first attempt to standardize the terminology in sedation provision was in 2008, when the Consensus Panel on Sedation Research of Pediatric Emergency Research Canada and the Pediatric Emergency Care Applied Research Network issued so-called “Quebec Guidelines,” a set of definitions which could be adopted by all sedation providers.[10] In 2010, the World Society of Intravenous Anesthesia established the International Sedation Task Force (ISTF), which comprised of members from different countries and backgrounds to establish globally accepted definitions of adverse events which were objective, reproducible, and applicable to all settings worldwide, and which focused on events of clinical significance (“Sedation/anesthesia in pediatric radiology”). ISTF has also produced a standardized sedation outcome reporting tool and aims to establish an international consensus and produce a sedation monitoring record to perform and document preprocedure assessment, monitoring, and discharge in any sedation procedure.[11]
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Definition of Sedation
Initially, there were three levels of sedation that were recognized, conscious sedation, deep sedation, and GA. However, soon it was acknowledged that the terminology of conscious sedation could not be used for pediatric population especially the young children.[12]
Sedation in general is defined as “a technique in which the use of a drug or drugs produces a state of depression of the central nervous system enabling treatment to be performed.”[13] Three levels of sedation are defined in addition to GA.
Minimal sedation: A state during which patients are awake and calm and respond normally to verbal commands. “Although cognitive function and coordination may be impaired, ventilatory and cardiovascular functions are unaffected.”
Moderate sedation: A state during which patients are sleepy but respond purposefully to verbal commands (known as conscious sedation in dentistry) or light tactile stimulation (reflex withdrawal from a painful stimulus is not a purposeful response). No interventions are required to maintain a patent airway. Spontaneous ventilation is adequate. Cardiovascular function is usually maintained.
Deep sedation: In this plane of sedation patients are asleep and cannot easily be roused but do respond purposefully to repeated or painful stimulation. The ability to maintain ventilatory function independently may be impaired. Patients may require assistance to maintain a patent airway.
GA: This is a drug-induced loss of consciousness during which patients are not arousable, even by painful stimulation. “The ability to maintain independent ventilatory function is often impaired.” They need assistance with maintaining their airway and positive pressure ventilation is often required to maintain adequate gas exchange. Cardiovascular function may also be impaired.
Dissociative sedation, another category has been added by the European pediatricians. This is defined as a trance-like cataleptic state induced by the dissociative agent ketamine or s-ketamine and characterized by profound analgesia and amnesia with retention of protective airway reflexes, spontaneous respiration, and cardiopulmonary stability.[14]
Although sedation and anesthesia have well-defined definitions, it can be quite dangerous to adhere to a state strictly during a procedure. The dose of drugs required for moderate sedation in one child can lead to deep sedation in the other or even apnea and airway obstruction that might necessitate same level of care and supervision/intervention as GA[9] ([Table 1]).
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Adverse Effects and Complications to Sedation and General Anesthesia
SAGA can lead to adverse effects and complications because of the drugs on ventilatory and cardiovascular systems that are usually dose-dependent but lower dosages can lead to significant side effects in patients with underlying comorbidities or congenital problems. The individual side effects characteristic of a particular drug will be discussed later; however, the most prevalent side effects are usually respiratory in nature which includes apnea, upper airway obstruction due to tongue fall, and hypoventilation, all of which can lead to hypoxemia. Cardiovascular side effects can also occur and include fluctuations in heart rate and blood pressure depending on the drug used. Other adverse effects of SAGA which can occur in practice include postsedation nausea, vomiting, and allergic reaction to the underlying drugs.
After studying 95 sedation-related adverse events with 51 deaths and 9 permanent neurological injuries, Cote et al concluded that most of the events were preventable and due to human errors rather than the side effects of the drugs. Certain conclusions that can be drawn from numerous studies are[15] [16] [17]:
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All classes of drugs have been associated with problems even when administered in recommended doses and therefore there is no one category that can be recommended or is entirely safe.
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Adverse events more frequently involved use of more than one drug (three or more being particularly dangerous).
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Respiratory complications are the usual initial adverse events and cardiac arrests and neurological damage occurred as secondary adverse events secondary to hypoxemia.
Therefore, it seems that most of the mortalities and morbidities that take place are avoidable.
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Sedation and General Anesthesia—Personnel
There is a large variation in the expertise of personnel and background training that perform SAGA for radiological investigations with uniformity and guidelines followed throughout the country on one hand to different people administering different drugs according to their preference on the other in the absence of strict protocols.
In India there are no strict uniform guidelines that dictate the personnel who would be performing SAGA. The individual hospitals and standalone dedicated imaging centers generally use services of an anesthesiologist for GA with some using the same level of expertise and care for administering sedation and some on the other hand using the services of a general practitioner or an in-house radiologist having some experience in sedation. However, with increasing medico-legal problems many busy standalone centers have started employing full-time anesthesiologist.
In the United Kingdom, oral sedation is usually performed by sedation nurses who have had a structured training to deliver this service with knowledge of the procedure, the adverse effects of the drugs, and the skills to resuscitate the patients if required. However, the patients who need GA or are high risk depending on the underlying problems are taken care of by the anesthesia team.[18]
In Israel, there is a similar sedation program which involves specially trained nurses, all with intensive care backgrounds with pediatric anesthesiologists at the next level who deliver GA or deep sedation to those who fail a trial of nurse-administered sedation or are high-risk category.[11]
In the United States, there are several sedation models ranging from pediatricians to anesthesiologists who deliver SAGA. In the pediatrician-delivered model, pediatricians who can deliver propofol in hospital undergo a well-defined structured training program before they are allowed to deliver propofol-based SAGA independently with the immediate availability of an anesthesiologist for backup if needed.[11] Another model uses the services of emergency medicine physicians. The intensive care medicine physicians-delivered model provides SAGA by critical care physicians and practice nurses, with overall support and backup from anesthesiologist.
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Equipment and Monitoring
Although the pediatric diagnostic radiological procedures are usually short and do not involve any surgical stimulation, this should never diminish the level of care and monitoring. Most of the complications that take place during a surgery can happen during these procedures as well. Also, the level of monitoring should be the same for sedation and anesthesia.
The acronym that is used for the equipment and monitoring that should be available and is widely followed is the one recommended by AAP-SOAPME.[1]
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S – Suction—Suction catheters and/or Yankauer's suction with a functioning suction apparatus.
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O – Oxygen—Adequate oxygen supply with optimal backup and functioning flow meters/other devices to allow its delivery.
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A – Airway—Nasopharyngeal and oropharyngeal airways, laryngoscope blades, endotracheal (ET) tubes, supraglottic airway devices, stylets, bougie, face mask, bag–valve–mask/AMBU, or equivalent device.
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P – Pharmacy—All the basic drugs needed to support life during an emergency, including antagonists as indicated.
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M – Monitor—Functioning pulse oximeter with size-appropriate probes and other monitors (noninvasive blood pressure, end-tidal carbon dioxide monitors, electrocardiogram [ECG], stethoscopes) (“Procedural Sedation Learning Module - MNCYN”).
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E – Equipment—Special equipment or drugs for both anesthesia and resuscitation (e.g., defibrillator).
It is essential that all the above are checked on a daily/weekly/monthly basis as appropriate before the start of the first case in the morning as per the established protocols.
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Special Problems due to Imaging Modality for Sedation/GA
MRI
Although MRI involves the use of powerful magnetic fields and therefore is free from all the radiation exposure traditionally associated with diagnostic radiology, it has its own unique set of hazards. The powerful magnetic pull that can transform any ferrous containing article into a projectile object capable of causing severe physical injuries necessitates the use of MR-compatible equipment for delivering SAGA while all the noncompatible ones must be placed beyond the recommended boundaries.[19] The MR-compatible pulse oximeter, ECG electrodes, and capnograph tracing are not always available particularly in small diagnostic imaging institutes in developing countries and can impose a big challenge to the SAGA provider. This makes it essential to monitor the respiratory movements continuously to detect any early compromise.
Remote monitoring based on visual monitoring and observation of the patient during scanning is available at some places.[20] For the anesthetist, the main challenge is the inability to access the head end for positive pressure ventilation and/or insertion of an airway in case of respiratory complications and requires interruption of the procedure and the patient needs to be pulled out.
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CT Imaging
The risk of exposure to radiation generally prevents the caregiver from being physically present inside the room during the procedure and all that can be accessed is the readings on the monitor that are attached to the patient. Therefore, it is essential that immediately after administration of the drug the patient is monitored closely for vitals, adequate respiration, and it is ensured that there are no movements that can prevent acquisition of optimal images before the CT is started and it is only then that the SAGA provider leaves the room.
Pre-SAGA Assessment
Focused History and Clinical Examination
A thorough patient history, clinical examination, and investigations as indicated[9] are essential in the stratification of patients and ensuring that SAGA is delivered safely. Height, weight, and body mass index must be measured and ideally the drug dosages should be calculated beforehand.
The history taking and clinical examination should be performed as sincerely as for any other major procedure bearing in mind that all complications are possible. Particular attention should be given to the possibility of congenital problems, underlying comorbid diseases, allergies, and history of adverse reaction to anesthesia previously or in the family. If there is an underlying problem related to a system, then relevant investigations must be accessed or performed before taking up SAGA if required.
Airway assessment is equally important; however, it may not be possible to do it thoroughly in neonates, infants, and young children. A history of sleep apnea and obesity might indicate a higher risk of airway obstruction during SAGA.
The main purpose of doing the above is to arrive at the ASA status of the patient and assess whether the procedure can be safely performed or not. For instance, ASA 1 and 2 patients might be taken up for sedation by trained nurses in congruence with the local protocols and higher risk patients or those with difficult airways often require pediatric anesthetists/emergency physicians trained in sedation. Also, standalone imaging centers without adequate backup from other specialties might not want to do ASA 3 or greater risk patients.
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ASA Class Description
Below are the ASA class descriptions:
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Healthy patient (no physiological, physical, or psychological abnormalities).
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Patient with systemic disease without limitation of daily activities (e.g., controlled asthma, controlled diabetes).
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Patient with severe systemic disease that limits daily activities.
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Patient with an incapacitating disease that is a constant threat to life (head injury with risk of brain herniation).
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Moribund patient not expected to survive with or without surgery.
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A declared brain-dead patient whose organs are being removed for donor purposes.
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Fasting Guidelines
The same fasting guidelines should be followed that are used for surgical cases as aspiration of the gastric contents and the consequent complications can be life threatening.
The category of patients at high risk for aspiration should be identified as this may decide the method of securing the airway during GA (supraglottic device vs. ET tube). Also, the same might indicate the need for a periprocedure antireflux/antacid/proton-pump inhibitor prophylaxis ([Table 2]).
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Fasting Guidelines—Elective[18] Rule of 2–4-6
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-No clear fluids for 2 hours prior to the procedure.
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-No breast milk for 4 hours prior to the procedure.
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-No solids or formula feeds for 6 hours prior to the procedure.
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-Emergency procedures: Decision to proceed with sedation is based on the urgency of the procedure, depth of sedation required, and the available personnel.
Parental/Guardian Consent
The person who can give the consent varies depending on the age of the child and the national guidelines.
In India, parental/guardian consent is required for children under the age of 18 years and the consent is written and informed. The guidelines given by the Indian Council of Medical Research should be followed.
In the United Kingdom, children may be able to give consent to SAGA where they are either over 16 years (competency assumed) or of sufficient maturity that they are able to understand the procedure and give informed consent (Gillick competency). If a child aged 16 or more years does not have the capacity to consent, a person with parental responsibility can consent for them. It is essential that written and informed or verbal and informed consent is taken before the procedure is done. The mode of anesthesia, risk, and side effects should be discussed and documented in case of a verbal consent.[18]
In emergency situations, where the child is incompetent, and parents are not available the procedure and SAGA can be performed in the best interests of the patient.[21]
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Sedation and General Anesthesia Drugs
The drugs used for SAGA depend on the underlying procedure, the duration, patient factors, and the local guidelines. There are numerous agents employed for this purpose ranging from oral syrups, intramuscular/intravenous injections to volatile inhalational gases. A particular drug can be employed as the sole agent or in combination with drugs from other groups.
No data exist on whether a specific anesthetic technique is superior to others for MRI. Usher and Kearney[22] reported based on surveys in 11 Canadian medical institutes more than 50% use of total intravenous anesthesia with propofol for MRI. Another study conducted by Usher et al[23] demonstrated excellent airway preservation and rapid recovery using GA doses of propofol in children. Other studies have shown the safety and use of sevoflurane in infants.[24] [25] Recently, dexmedetomidine has been reported to be useful even in difficult airways.[26]
The main drawback of mild to moderate sedation is its high failure rate as compared with GA which increases the number of attempts required by the radiographers and considerably adds to the scan time.
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Most Used Medications
Oral
Chloral Hydrate and Triclofos
They are arguably the most frequently used sedative in infants and children under 2 years and continue to be used as the main agent for sedation in diagnostic pediatric radiology in developing countries. In recent years it has been employed even in children more than 2 years with considerable success. Parents feel more comfortable with an oral syrup for sedation for their child rather than a painful intravenous injection. As early as 1894, chloral hydrate has been used in children.[27]
Choral hydrate and triclofos are effective oral sedatives and metabolized to trichloroethanol. “Chloral hydrate has an unpleasant taste and causes gastric irritation; triclofos is more palatable but is slower and less potent (1 g triclofos = 600 mg chloral hydrate).” In a large study, approximately 2,000 children aged < 18 months received chloral hydrate (up to 100 mg/kg) without respiratory complications, but in another study, out of 854 children, 4 had airway obstruction, 11 vomited, and 6 had paradoxical reactions.[28] Chloral hydrate produces effective sedation in 80 to 90% of patients.[29] However, its unpredictable onset, long duration, lack of a reversal agent, and the possibility of the child waking up in the middle of the procedure requiring further dosages and attempts for scanning make it less than an ideal agent for sedation. Because of the abovementioned reasons, it is no longer used in some countries.
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Midazolam
It is available in oral form in some countries and can be given in the dose of 0.25 to 0.5 mg/kg (max: 20 mg). It takes approximately 20 minutes to act, and the duration can last up to 60 minutes. Side effects are mentioned in [Tables 3] and [4].
Abbreviations: IM, intramuscular; IV, intravenous.
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Monitoring
During Procedure
The operator should not be the same person responsible for monitoring the child during the procedure.[21] There should be dedicated personnel responsible for observing and recording the vitals and should be able to assist in resuscitation if required.
The vitals must be recorded continuously every 5 minutes with documentation of heart rate auscultation, oxygen saturation, capnography as appropriate, respiratory rate, and blood pressure.[30] The drugs administered with additional dosages to maintain anesthesia must also be recorded at the same time with record of adverse events if any. If contrast is given the same must be documented with exact time and dose to differentiate the allergic reaction due to contrast versus the side effects due to the anesthetic agent.
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After Procedure (Recovery Area)
The vitals should be recorded every 15 minutes and documented. The child can be discharged once the desired criteria are met. The discharge advice should be given in a document that mentions the relevant phone numbers and the nearest emergency facility to contact in case of a problem.
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Responsible Person
The child should be discharged from the treatment facility only when the parent, guardian, or other responsible person can stay with the patient continuously for a period of 24 hours or a greater duration till the child becomes completely normal and returns to his baseline.
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Discharge Criteria
The discharge criteria to be followed depends on the local guidelines and hospital policy but all involve the mandatory requirement of stable vital signs, consciousness, and absence of adverse effects like nausea and vomiting and optimal hydration.[9] [18] However, the commonly used criteria cannot be used to discharge children who have been given long-acting agents like chloral hydrate and triclofos. Malviya et al suggested that ensuring that the child can stay awake for 20 minutes when undisturbed should be a safe discharge criterion in such instances.[31]
On discharge, the responsible adult/parent should be given instructions on what to expect and how to manage the child after discharge. Children should remain under the responsible adult's supervision, and they should not participate in any activity that requires motor skills over that time. The potential problems that can arise, contact details of physicians, and the nearest available emergency services must be communicated on discharge ([Table 5]).
Abbreviation: BP, blood pressure.
Note: A score of 9 or more is required for discharge.
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Summary
With the advancements in imaging equipment and technology, availability of stronger magnets in MRI, shortened procedure time, and low threshold for imaging studies due to medico-legal concerns, volume of pediatric imaging studies has grown considerably over the last two decades and consequently has increased the procedures being done under sedation and GA. Every procedure that involves the use of SAGA can lead to adverse effects and complications. Therefore, to practice safe care one needs to establish and follow the local protocols[32] for preprocedure assessment, choice of drug, maintain an effective and continuous communication with the radiologist and radiographer, use appropriate monitoring, and adhere strictly to the discharge criteria. All health care providers who deliver SAGA for pediatric diagnostic imaging should be competent in airway assessment and skilled in the resuscitation of this subset of patients. There are wide variations in the techniques and personnel employed for this purpose across the world; however, the desired outcome in all countries is the same that is to deliver safe, effective SAGA with acquisition of optimal images for the correct diagnosis.
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Conflict of Interest
None declared.
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References
- 1 American Academy of Pediatrics. American Academy of Pediatric Dentistry, Cote CJ, Wilson S; Work Group on Sedation. “Guidelines for monitoring and management of pediatric patients during and after sedation for diagnostic and therapeutic procedures: an update.” (“Local anesthetic systemic toxicity: current perspectives”) (“Complications associated with intravenous midazolam and ...”). Pediatrics 2006; 118: 2587-2602
- 2 Green SM, Rothrock SG, Lynch EL. et al. Intramuscular ketamine for pediatric sedation in the emergency department: safety profile in 1,022 cases. Ann Emerg Med 1998; 31 (06) 688-697
- 3 Malviya S, Voepel-Lewis T, Tait AR. Adverse events and risk factors associated with the sedation of children by nonanesthesiologists. Anesth Analg 1997; 85 (06) 1207-1213
- 4 The Royal College of Radiologists. Safe sedation, analgesia and anaesthesia within the radiology department. September 2003. Accessed May 30, 2011 at: http://www.rcr.ac.uk/publications.aspx?PageID5310&
- 5 Ruess L, O'Connor SC, Mikita CP, Creamer KM. Sedation for pediatric diagnostic imaging: use of pediatric and nursing resources as an alternative to a radiology department sedation team. Pediatr Radiol 2002; 32 (07) 505-510
- 6 Malviya S, Voepel-Lewis T, Eldevik OP, Rockwell DT, Wong JH, Tait AR. Sedation and general anaesthesia in children undergoing MRI and CT: adverse events and outcomes. Br J Anaesth 2000; 84 (06) 743-748
- 7 Committee on Drugs, Section on Anesthesiology, American Academy of Pediatrics. Guidelines for the elective use of conscious sedation, deep sedation, and general anesthesia in pediatric patients. Pediatrics 1985; 76: 317-321
- 8 Cravero JP, Blike GT. Review of pediatric sedation. Anesth Analg 2004; 99 (05) 1355-1364
- 9 Levati A, Paccagnella F, Pietrini D. et al; SIAARTI. SIAARTI-SARNePI Guidelines for sedation in pediatric neuroradiology. Minerva Anestesiol 2004; 70 (10) 675-697
- 10 Green SM, Yealy DM. Procedural sedation goes Utstein: the Quebec guidelines. Ann Emerg Med 2009; 53 (04) 436-438
- 11 Gozal D, Mason KP. Pediatric sedation: a global challenge. Int J Pediatr 2010; 2010: 701257
- 12 Coté CJ. “Conscious sedation”: time for this oxymoron to go away!. J Pediatr 2001; 139 (01) 15-17
- 13 doh.gov.uk. [homepage on the internet]. London, UK: Department of Health; 2003. . Available at: http://www.advisorybodies.doh.gov.uk/sdac/conscious_sedationdec03
- 14 Meyer S, Grundmann U, Gottschling S, Kleinschmidt S, Gortner L. Sedation and analgesia for brief diagnostic and therapeutic procedures in children. Eur J Pediatr 2007; 166 (04) 291-302
- 15 Coté CJ, Karl HW, Notterman DA, Weinberg JA, McCloskey C. Adverse sedation events in pediatrics: analysis of medications used for sedation. Pediatrics 2000; 106 (04) 633-644
- 16 Coté CJ, Notterman DA, Karl HW, Weinberg JA, McCloskey C. Adverse sedation events in pediatrics: a critical incident analysis of contributing factors. Pediatrics 2000; 105 (4 Pt 1): 805-814
- 17 Cravero JP, Blike GT, Beach M. et al; Pediatric Sedation Research Consortium. Incidence and nature of adverse events during pediatric sedation/anesthesia for procedures outside the operating room: report from the Pediatric Sedation Research Consortium. Pediatrics 2006; 118 (03) 1087-1096
- 18 National Institute for Health and Clinical Excellence. NICE clinical guideline 112. Sedation in children and young people. December 2010. Accessed May 30, 2011 at: http://www.nice.org.uk/nicemedia/live/13296/52130/52130.pdf
- 19 Arlachov Y, Ganatra RH. Sedation/anaesthesia in paediatric radiology. Br J Radiol 2012; 85 (1019): e1018-e1031
- 20 Gooden CK. Anesthesia for magnetic resonance imaging. Curr Opin Anaesthesiol 2004; 17 (04) 339-342
- 21 Scottish Intercollegiate Guidelines Network. Safe sedation of children undergoing diagnostic and therapeutic procedures. A National Clinical Guideline. May 2004. Accessed June 7, 2011 at: http://www.blackwellpublishing.com/medicine/bmj/nnf5/pdfs/guidelines/Scottish_guideline.pdf
- 22 Usher A, Kearney R. Anesthesia for magnetic resonance imaging in children: a survey of Canadian pediatric centres. Can J Anaesth 2003; 50 (04) 425
- 23 Usher AG, Kearney RA, Tsui BCH. Propofol total intravenous anesthesia for MRI in children. Paediatr Anaesth 2005; 15 (01) 23-28
- 24 Sury MR, Harker H, Thomas ML. Sevoflurane sedation in infants undergoing MRI: a preliminary report. Paediatr Anaesth 2005; 15 (01) 16-22
- 25 DeSanctis Briggs V. Magnetic Resonance Imaging under sedation in newborns and infants: a study of 640 cases using sevoflurane. Paediatr Anaesth 2005; 15: 9-15
- 26 Bhat R, Mitragotri MV. A child with difficult airway for magnetic resonance imaging: is dexmedetomidine useful?. Indian J Anaesth 2015; 59 (10) 687-688
- 27 Buck ML. Chloral hydrate use during infancy. Neonatal Pharmacol Q 1992; 1: 31-37
- 28 Sury MRJ. FRCA paediatric sedation. Contin Educ Anaesth Crit Care Pain 2004; 4 (04) 118-122
- 29 Buck ML. The use of chloral hydrate in infants and children. Pediatric Pharmacotherapy. A Monthly Newsletter for Health Care Professionals from the University of Virginia Children's Hospital. September 2005;11(9):4. Available at: http://www.medicine.virginia.edu/clinical/departments/pediatrics/education/pharm-news/2001-2005/200509.pdf
- 30 Kaplan RF, Yaster M, Srafford MA, Cote CJ. Paediatric sedation for diagnostic and therapeutic procedures outside the operating room. In: Cote CJ, Todres ID, Ryan JF, Goudsouzian NG. eds. A Practice of Anaesthesia for Infants and Children. Philadelphia, PA: WB Saunders Company; 2001: 584-609
- 31 Malviya S, Voepel-Lewis T, Ludomirsky A, Marshall J, Tait AR. Can we improve the assessment of discharge readiness?: A comparative study of observational and objective measures of depth of sedation in children. Anesthesiology 2004; 100 (02) 218-224
- 32 Pitetti R, Davis PJ, Redlinger R, White J, Wiener E, Calhoun KH. Effect on hospital-wide sedation practices after implementation of the 2001 JCAHO procedural sedation and analgesia guidelines. Arch Pediatr Adolesc Med 2006; 160 (02) 211-216
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Article published online:
19 September 2023
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References
- 1 American Academy of Pediatrics. American Academy of Pediatric Dentistry, Cote CJ, Wilson S; Work Group on Sedation. “Guidelines for monitoring and management of pediatric patients during and after sedation for diagnostic and therapeutic procedures: an update.” (“Local anesthetic systemic toxicity: current perspectives”) (“Complications associated with intravenous midazolam and ...”). Pediatrics 2006; 118: 2587-2602
- 2 Green SM, Rothrock SG, Lynch EL. et al. Intramuscular ketamine for pediatric sedation in the emergency department: safety profile in 1,022 cases. Ann Emerg Med 1998; 31 (06) 688-697
- 3 Malviya S, Voepel-Lewis T, Tait AR. Adverse events and risk factors associated with the sedation of children by nonanesthesiologists. Anesth Analg 1997; 85 (06) 1207-1213
- 4 The Royal College of Radiologists. Safe sedation, analgesia and anaesthesia within the radiology department. September 2003. Accessed May 30, 2011 at: http://www.rcr.ac.uk/publications.aspx?PageID5310&
- 5 Ruess L, O'Connor SC, Mikita CP, Creamer KM. Sedation for pediatric diagnostic imaging: use of pediatric and nursing resources as an alternative to a radiology department sedation team. Pediatr Radiol 2002; 32 (07) 505-510
- 6 Malviya S, Voepel-Lewis T, Eldevik OP, Rockwell DT, Wong JH, Tait AR. Sedation and general anaesthesia in children undergoing MRI and CT: adverse events and outcomes. Br J Anaesth 2000; 84 (06) 743-748
- 7 Committee on Drugs, Section on Anesthesiology, American Academy of Pediatrics. Guidelines for the elective use of conscious sedation, deep sedation, and general anesthesia in pediatric patients. Pediatrics 1985; 76: 317-321
- 8 Cravero JP, Blike GT. Review of pediatric sedation. Anesth Analg 2004; 99 (05) 1355-1364
- 9 Levati A, Paccagnella F, Pietrini D. et al; SIAARTI. SIAARTI-SARNePI Guidelines for sedation in pediatric neuroradiology. Minerva Anestesiol 2004; 70 (10) 675-697
- 10 Green SM, Yealy DM. Procedural sedation goes Utstein: the Quebec guidelines. Ann Emerg Med 2009; 53 (04) 436-438
- 11 Gozal D, Mason KP. Pediatric sedation: a global challenge. Int J Pediatr 2010; 2010: 701257
- 12 Coté CJ. “Conscious sedation”: time for this oxymoron to go away!. J Pediatr 2001; 139 (01) 15-17
- 13 doh.gov.uk. [homepage on the internet]. London, UK: Department of Health; 2003. . Available at: http://www.advisorybodies.doh.gov.uk/sdac/conscious_sedationdec03
- 14 Meyer S, Grundmann U, Gottschling S, Kleinschmidt S, Gortner L. Sedation and analgesia for brief diagnostic and therapeutic procedures in children. Eur J Pediatr 2007; 166 (04) 291-302
- 15 Coté CJ, Karl HW, Notterman DA, Weinberg JA, McCloskey C. Adverse sedation events in pediatrics: analysis of medications used for sedation. Pediatrics 2000; 106 (04) 633-644
- 16 Coté CJ, Notterman DA, Karl HW, Weinberg JA, McCloskey C. Adverse sedation events in pediatrics: a critical incident analysis of contributing factors. Pediatrics 2000; 105 (4 Pt 1): 805-814
- 17 Cravero JP, Blike GT, Beach M. et al; Pediatric Sedation Research Consortium. Incidence and nature of adverse events during pediatric sedation/anesthesia for procedures outside the operating room: report from the Pediatric Sedation Research Consortium. Pediatrics 2006; 118 (03) 1087-1096
- 18 National Institute for Health and Clinical Excellence. NICE clinical guideline 112. Sedation in children and young people. December 2010. Accessed May 30, 2011 at: http://www.nice.org.uk/nicemedia/live/13296/52130/52130.pdf
- 19 Arlachov Y, Ganatra RH. Sedation/anaesthesia in paediatric radiology. Br J Radiol 2012; 85 (1019): e1018-e1031
- 20 Gooden CK. Anesthesia for magnetic resonance imaging. Curr Opin Anaesthesiol 2004; 17 (04) 339-342
- 21 Scottish Intercollegiate Guidelines Network. Safe sedation of children undergoing diagnostic and therapeutic procedures. A National Clinical Guideline. May 2004. Accessed June 7, 2011 at: http://www.blackwellpublishing.com/medicine/bmj/nnf5/pdfs/guidelines/Scottish_guideline.pdf
- 22 Usher A, Kearney R. Anesthesia for magnetic resonance imaging in children: a survey of Canadian pediatric centres. Can J Anaesth 2003; 50 (04) 425
- 23 Usher AG, Kearney RA, Tsui BCH. Propofol total intravenous anesthesia for MRI in children. Paediatr Anaesth 2005; 15 (01) 23-28
- 24 Sury MR, Harker H, Thomas ML. Sevoflurane sedation in infants undergoing MRI: a preliminary report. Paediatr Anaesth 2005; 15 (01) 16-22
- 25 DeSanctis Briggs V. Magnetic Resonance Imaging under sedation in newborns and infants: a study of 640 cases using sevoflurane. Paediatr Anaesth 2005; 15: 9-15
- 26 Bhat R, Mitragotri MV. A child with difficult airway for magnetic resonance imaging: is dexmedetomidine useful?. Indian J Anaesth 2015; 59 (10) 687-688
- 27 Buck ML. Chloral hydrate use during infancy. Neonatal Pharmacol Q 1992; 1: 31-37
- 28 Sury MRJ. FRCA paediatric sedation. Contin Educ Anaesth Crit Care Pain 2004; 4 (04) 118-122
- 29 Buck ML. The use of chloral hydrate in infants and children. Pediatric Pharmacotherapy. A Monthly Newsletter for Health Care Professionals from the University of Virginia Children's Hospital. September 2005;11(9):4. Available at: http://www.medicine.virginia.edu/clinical/departments/pediatrics/education/pharm-news/2001-2005/200509.pdf
- 30 Kaplan RF, Yaster M, Srafford MA, Cote CJ. Paediatric sedation for diagnostic and therapeutic procedures outside the operating room. In: Cote CJ, Todres ID, Ryan JF, Goudsouzian NG. eds. A Practice of Anaesthesia for Infants and Children. Philadelphia, PA: WB Saunders Company; 2001: 584-609
- 31 Malviya S, Voepel-Lewis T, Ludomirsky A, Marshall J, Tait AR. Can we improve the assessment of discharge readiness?: A comparative study of observational and objective measures of depth of sedation in children. Anesthesiology 2004; 100 (02) 218-224
- 32 Pitetti R, Davis PJ, Redlinger R, White J, Wiener E, Calhoun KH. Effect on hospital-wide sedation practices after implementation of the 2001 JCAHO procedural sedation and analgesia guidelines. Arch Pediatr Adolesc Med 2006; 160 (02) 211-216