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Drug Res (Stuttg) 2016; 66(11): 597-602
DOI: 10.1055/s-0042-112365
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

The Effect of Muscarinic Receptor Modulators on the Antinociception Induced by CB2 Receptor Agonist, JWH133 in Mice

M. Alipour
1   Department of Physiology and Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
,
F. Fekrmandi
2   Department of Medicine, McGill University, Montreal, Canada
,
S. Onsori
1   Department of Physiology and Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
,
P. Tabrizian
1   Department of Physiology and Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
,
M. R. Jafari
1   Department of Physiology and Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
› Author Affiliations
Further Information

Publication History

received 30 April 2016

accepted 01 July 2016

Publication Date:
09 August 2016 (online)

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Abstract

There is no published study regarding the interaction between muscarinic receptor modulators and antinociception induced by cannabinoid receptor (CB2) agonist. The effect of pilocarpine (a muscarinic agonist) and atropine (a muscarinic antagonist) on JWH-133 (a CB2 agonist) induced analgesia in mice was studied. First the analgesic effect of JWH-133 (0.001–1 mg/Kg) or pilocarpine (2.5–20 mg/kg) or atropine (0.2–5 mg/kg) was evaluated. Subsequently, the effect of co-administration of pilocarpine (2.5 mg/kg) or atropine (5 mg/kg) and JWH-133 (0.001–1 mg/Kg) were studied too. JWH-133 and pilocarpine provoked antinociception in mice but atropine did not. Pilocarpine potentiated the analgesic effect of JWH-133 but atropine antagonized that. It can be concluded that JWH-133 induced antinociception is affected by muscarinic receptor modulators in mice.

Key words

antinociception - JWH-133 - pilocarpine - atropine - formalin test - mice
 

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