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DOI: 10.1055/s-0041-1733925
Hemostatic Biomarkers and Cancer Prognosis: Where Do We Stand?
Funding The HYPERCAN study (ClinicalTrials.gov # NCT0262281) is funded by AIRC “5xMILLE” n. 12237 grant from the “Italian Association for Cancer Research (AIRC).”![](https://www.thieme-connect.de/media/sth/202108/lookinside/thumbnails/10-1055-s-0041-1733925_02924-1.jpg)
Abstract
Cancer patients are characterized by hypercoagulable state and an increased rate of thrombotic events, the most common being venous thromboembolism. Several hemostatic pathways that are significantly implicated in mechanisms of thromboembolic disease are also involved in growth, invasion, and metastatic spread of malignant cells as well in tumor-induced neo-angiogenesis. This close connection between cancer and the hemostatic system has prompted numerous studies on the role of alterations in the level plasma biomarkers of the different compartments of hemostasis in predicting cancer prognosis. In this review, we collect the results of several exemplificative studies that have evaluated clotting activation biomarkers in relation to different cancer outcomes with a final emphasis on current research and forthcoming directions in this field.
Keywords
cancer - hypercoagulable state - tumor cell - hemostatic system - biomarkers - fibrinogen - plasminogen activator inhibitor - D-dimer - fibrinogen - cellular microparticles - thrombin - neutrophil extracellular traps - mortality - plasminogen activator - disease recurrence - disease progressionPublication History
Article published online:
27 August 2021
© 2021. Thieme. All rights reserved.
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