CC BY-NC-ND 4.0 · Laryngorhinootologie 2021; 100(S 02): S284
DOI: 10.1055/s-0041-1728856
Abstracts
Rhinology: Olfaction / Gustology

Factors Associated with Relevant Olfactory Recovery After Olfactory Training: A retrospective study including 601 participants

DT Liu
1   Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Wien, Austria
,
R Pellegrino
3   Department of Food Science, Institute of Agriculture, University of Tennessee, Knoxville, United States
,
M Sabha
2   Smell and Taste Clinic, Department of Otorhinolaryngology, Medical Faculty Carl-Gustav Carus, Technical University of Dresden, Dresden
,
A Altundag
4   Department of Otorhinolaryngology, Biruni University Medicine Faculty, Istanbul, Turkey
,
M Damm
5   ENT-Medicine Cologne (HNO-Heilkunde Köln) and University Hospitals of Cologne, Köln
,
SC Poletti
2   Smell and Taste Clinic, Department of Otorhinolaryngology, Medical Faculty Carl-Gustav Carus, Technical University of Dresden, Dresden
,
I Croy
2   Smell and Taste Clinic, Department of Otorhinolaryngology, Medical Faculty Carl-Gustav Carus, Technical University of Dresden, Dresden
,
A Hähner
2   Smell and Taste Clinic, Department of Otorhinolaryngology, Medical Faculty Carl-Gustav Carus, Technical University of Dresden, Dresden
,
A Oleszkiewicz
6   Institute of Psychology, University of Wroclaw, Wroclaw, Poland
,
M Cuevas
2   Smell and Taste Clinic, Department of Otorhinolaryngology, Medical Faculty Carl-Gustav Carus, Technical University of Dresden, Dresden
,
T Hummel
2   Smell and Taste Clinic, Department of Otorhinolaryngology, Medical Faculty Carl-Gustav Carus, Technical University of Dresden, Dresden
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    Background Olfactory training (OT) represents a therapeutic option for multiple etiologies of olfactory dysfunction (OD) that also benefits normosmic subjects. In this retrospective study, we report the effectiveness of OT and factors associated with relevant changes in olfactory function (OF) in large groups of normosmic participants and patients with OD, including a control group that performed no training.

    Methods This was a retrospective pooled analysis including 2 treatment cohorts of 8 previously published studies. Adult participants that either presented with the major complaint of quantitative OD or normosmic volunteers were recruited at various ENT clinics and received OT or no training. The outcome was based on changes in objective olfactory test scores after OT.

    Results A total of 601 patients with OD or normosmic subjects were included. OT was more effective compared to no training. No interaction was found between OT and OF. In multivariate analysis, higher baseline OF (adjusted odds ratio, aOR, 0.93) and posttraumatic (aOR, 0.29) or idiopathic OD (aOR, 0.18) compared to postinfectious causes were significantly associated with lower odds of relevant improvements in patients with OD receiving OT. Subgroup analysis of normosmic participants receiving OT further revealed a significant association of lower age and baseline olfactory function with improvements of overall OF.

    Conclusions This study demonstrated that OT was more effective than no training in patients with various causes of OD. Additionally, baseline olfactory performance and etiology of OD were identified as important factors associated with relevant improvements after OT.

    Poster-PDF A-1275.pdf

    Reisestipendiums für Riech und Schmeckforschung der Arbeitsgemeinschaft Olfaktologie/Gustologie der Deutschen Gesellschaft für Hals- Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn


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    Conflict of interest

    Der Erstautor gibt keinen Interessenskonflikt an.

    Address for correspondence

    Prof. Dr.med. Hummel Thomas
    Smell and Taste Clinic, Department of Otorhinolaryngology, Medical Faculty Carl-Gustav Carus, Technical University of Dresden
    Dresden

    Publication History

    Article published online:
    13 May 2021

    © 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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