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Neuropediatrics 2021; 52(04): 268-273
DOI: 10.1055/s-0041-1726127
Original Article

Bilateral Motor Responses to Transcranial Magnetic Stimulation in Preterm Children at 9 Years of Age

A. Marita Valkama 
1   Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland
2   PEDEGO Research Center, University of Oulu, Oulu, Finland
3   Medical Research Center Oulu, University of Oulu, Oulu, Finland
,
Seppo O. Rytky
4   Department of Clinical Neurophysiology, Oulu University Hospital, Oulu, Finland
,
Päivi M. Olsén
1   Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland
2   PEDEGO Research Center, University of Oulu, Oulu, Finland
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Abstract

Objective This study was aimed to evaluate motor tracts integrity in nondisabled preterm-born (PT) children at 9 years of age.

Methods Overall, 18 PT and 13 term-born (T) children without motor disability were assessed by transcranial magnetic stimulation (TMS). Motor-evoked potentials (MEPs) were measured bilaterally from the abductor pollicis brevis (APB) and the tibialis anterior (TA) muscles. Muscle responses could be stimulated from all patients.

Results Overall, 83.3 and 23.1% of PT and T children, respectively, had mild clumsiness (p = 0.001). One PT and three T children had immediate bilateral responses in the upper extremities. Seven PT children had delayed ipsilateral APB responses after left and ten after right TMS. Three controls had delayed ipsilateral responses. Ipsilateral lower extremity responses were seen in one PT after right and two PT children and one T child after left TMS. The results did not correlate to groups, genders, clumsiness, or handedness.

Conclusion Children of PT and T may have bilateral motor responses after TMS at 9 years of age. Ipsilateral conduction emerges immediately or more often slightly delayed and more frequently in upper than in lower extremities.

Significance Bilateral motor conduction reflects developmental and neurophysiological variability in children at 9 years of age. MEPs can be used as a measure of corticospinal tract integrity in PT children.

Keywords

clumsiness - motor-evoked potentials - preterm - transcranial magnetic stimulation


Publication History

Received: 23 March 2020

Accepted: 20 January 2021

Article published online:
11 March 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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