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DOI: 10.1055/s-0041-1725156
Enhanced Recovery After Surgery Protocol in Emergency Laparotomy: A Randomized Control Study
Abstract
Introduction There is established evidence on the role of enhanced recovery after surgery (ERAS) protocols in elective surgeries but its effectiveness in emergency surgeries has been nominally studied. We aimed at studying the feasibility and effectiveness of ERAS protocols in patients undergoing emergency abdominal surgery for intestinal perforation and small bowel obstruction and compare their surgical outcomes with conventional care.
Materials and methods This prospective randomized study was performed for a period of 16 months. A total of 100 patients presenting either with intestinal perforation or acute small bowel obstruction were recruited; 50 each in the ERAS and the conventional care groups. The primary outcomes studied were the postoperative length of stay and 30-day morbidity and mortality.
Results It was seen that the median (interquartile range) of the duration of hospital stay in the ERAS group was 4 (1) days while it was 7 (3) days in the conventional care group, which was statistically significant (W = 323.000, p ≤ 0.001). Similarly, postoperative morbidities like a chest infection and surgical site infections) were significant in the conventional care group.
Conclusion The ERAS protocols are safe and effective in emergency surgeries and result in a better postoperative outcome.
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Keywords
emergency gastrointestinal surgery - enhanced recovery after surgery protocol - emergency laparotomyEmergency surgery can be defined as any surgery that deals with an acute threat to life, organ, or tissue due to trauma, any acute disease process, acute exacerbation of the chronic disease, or a complication of a surgical or an interventional procedure.[1] These conditions require early surgical intervention, preferably within 24 hours, as they are associated with a high incidence of morbidity and mortality with rates as high as 80%.[2] These conditions result in an accentuated surgical stress response resulting in an increased catabolic state of the patient and the development of insulin resistance, which is a key element in prolonged recovery and increased morbidity.[3] This theory encouraged the development of a multimodal perioperative care pathway which was designed to reduce this surgical stress response, which would lead to early postoperative recovery as well as reduced length of hospital stay (LOS). This was termed as “enhanced recovery after surgery” (ERAS) or famously known as the “fast track” protocols which were developed by a Danish professor named Henrik Kehlet.[4] [5] [6] Intestinal obstructions and perforations constitute a major part of acute abdominal conditions presenting to us in our emergency department and are associated with a high incidence of morbidity and mortality if not timely intervened. So, implementation of ERAS protocols in this setting may decrease the enhanced surgical stress response and thus lead to enhanced postoperative recovery. This study was aimed to know the feasibility and efficacy of ERAS protocols in patients undergoing emergency abdominal surgery for intestinal perforation and acute intestinal obstruction.
Materials and Methods
It was a prospective randomized clinical study performed at All India Institute of Medical Sciences, Rishikesh, India. The duration of this study was 16 months, from January 2019 till April 2020 after ethical clearance from the institutional ethics committee (reference number 282/IEC/PGM/2018), and it was conducted in the Department of Surgery in collaboration with the Department of Anesthesiology of our institution. The trial is registered in Clinical Trials Registry–India (CTRI) with the registration number CTRI/2019/09/021282. The sample size in each group was calculated by PASS 11 (NCSS Statistical Software, Wilton, Connecticut) and length of hospital stay was used for power analysis as it was the only primary outcome that could be predicted. The level of significance was set to 5% and the power of the test as 80%. The ratio of sample size in the control group (conventional care group) and the intervention group (ERAS group) was 1:1 and the total sample size is taken was 100—50 in each group. The inclusion criteria were patients aged18 years and older of either sex presenting with acute intestinal obstruction or intestinal perforation diagnosed preoperatively and planned for emergency laparotomy, patients who gave informed consent for the study, and patients who were hemodynamically stable (i.e., systolic blood pressure equal to or above 90 mm Hg) or falling under American Society of Anesthesiologists (ASA) grade I–IIIe (“e” stands for emergency). The exclusion criteria were patients who were pregnant; patients on chronic steroids; patients with chronic obstructive pulmonary disease; patients with malignant ulcers confirmed by histopathological examination, laparoscopic surgeries, and acute abdominal trauma; and patients who required postoperative intensive care unit (ICU) care. The patients were randomly divided into two groups using computer-generated allocation software (random allocation software) and allocation concealment was done by “sealed envelope technique” to prevent prior knowledge of treatment assignment. The numbers were assigned in strict chronological order and the patients were entered in sequence. The patients in both groups were provided with detailed information about the clinical study and the risks and benefits of both protocols, and a verbal and written informed consent was taken. The patients were then assessed clinically and radiologically where a clinical assessment was done by a detailed history and examination of the patient, routine investigations, preanesthetic checkup, and risk stratification while the radiological assessment was done with an X-ray of the abdomen (erect and supine) and an ultrasonography (USG) of the whole abdomen. Contrast-enhanced computed tomography (CECT)/noncontrast computed tomography (NCCT) of the abdomen was reserved for cases of small and large bowel obstruction where the diagnosis was unclear or to delineate the etiology of obstruction. For the ERAS group, the points that could be applied in emergency laparotomy are included in [Table 1] and those for conventional care in [Table 2], respectively. An objective analysis of the concerned parameters was performed with the least risk of bias. Strict adherence to ERAS protocols was followed and compliance of the patients was ensured to both management strategies. All cases underwent exploratory laparotomy through a midline incision under general anesthesia following the standard anesthetic protocol of balanced anesthesia with short-acting anesthetic agents. Peptic ulcer perforations were repaired primarily by modified Graham's omental patch whereas ileal perforation was managed either through primary repair or ileostomy. Intestinal obstructions were treated by band division, adhesiolysis, creating a diversion ileostomy, or colostomy or by resection and anastomosis in case of tubercular strictures. Postoperative management was done according to the defined protocols in each group and the patients were discharged when the discharge criteria (i.e., hemodynamically stable, ambulatory, orally accepting) were met.. The patients were assessed for postoperative complications, LOS, readmission rate, and mortality and were followed till 30 days from surgery. The primary endpoints were the LOS and morbidity and mortality during the first 30 days after surgery which included surgical site infections ([SSIs] both superficial and deep), postoperative ileus, and pulmonary complications including atelectasis and pleural effusion. The secondary endpoints were the time to first flatus, the time elapsed until the resumption of oral feeding, the need for nasogastric tube reinsertion, the need of extra analgesics for pain relief, 30-day readmission, and re-exploration.
Preoperative |
Intraoperative |
Postoperative |
---|---|---|
Counseling and written informed consent |
Balanced anesthesia with short acting drugs |
Removal of nasogastric tube in all cases in the immediate postoperative period or within 6 hours postsurgery if the patient's consciousness is decreased |
Nil by mouth of 6 hours for solids and 2 hours for clear liquids |
Regional anesthesia in the form of epidural analgesia |
Removal of urinary catheter on postoperative day 1 |
Antibiotic prophylaxis |
Strict intraoperative fluid management |
Early mobilization within 6 hours of surgery |
Foley's catheterization and nasogastric tube insertion |
Restricted use of intra-abdominal drains |
Oral sips after removal of nasogastric tube on postoperative day 0 followed by soft diet on postoperative day 1 |
Initial resuscitation |
Routine use of warmers |
Strict fluid management post operatively and early discontinuation of intravenous fluids with resumption of oral feeds |
Central venous catheter insertion and IV fluid according to CVP |
Postoperative nausea and vomiting prophylaxis |
Early removal of abdominal drains on postoperative day 2 |
Postoperative nausea and vomiting prophylaxis |
||
Opioid sparing multimodal analgesia |
||
Early discharge after the patient is accepting soft diet |
Abbreviations: ERAS, enhanced recovery after surgery; IV, intravenous; CVP, Central venous pressure.
Preoperative |
Intraoperative |
Postoperative |
---|---|---|
Written informed consent |
Balanced anesthesia with short acting anesthetic agents |
Retaining the nasogastric tube till the patient passes flatus |
Nasogastric tube and urinary catheter insertion |
No regional anesthesia/analgesia |
Allowing oral sips only after passage of flatus and soft diet after passage of feces |
Nil by mouth of at least 8 hours |
Routine insertion of drains |
Nausea and vomiting prophylaxis |
Crystalloid infusion and resuscitation |
Intraoperative fluid management |
Removal of urinary catheters on postoperative day 1 |
Antibiotic prophylaxis |
No routine use of warmers |
Perioperative use of opioids |
Nausea and vomiting prophylaxis |
No routine insertion of central venous catheter |
Early mobilization after 12 hours |
discharge once they had passed feces and were taking adequate oral feeds |
Statistical Analysis
The statistical analysis was performed using the IBM SPSS v23 software (Armonk, NY). Discrete variables were represented as counts and percentages. Mean, standard deviation, and median were used for continuous data. Parametric tests (student t-test) were used to make group comparisons when the data showed a normal distribution. Nonparametric tests (Wilcoxon test) were used when the data were not normally distributed within the two groups. Fischer's exact test and Pearson's chi-square test were used for categorical data. Odds ratio and relative risk were calculated for dichotomous outcomes. A p-value of less than 0.05 was considered statistically significant.
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Results
A total of 100 consecutive patients presenting with acute intestinal obstruction and intestinal perforation were enrolled in the study who fulfilled the inclusion criteria. Out of the hundred, 75 patients were male and 25 were females ([Fig. 1]). Both groups were similar in terms of distribution of gender (χ2 = 0.053, p = 0.817). These patients were then assigned the respective groups according to the randomization and underwent exploratory laparotomy. Both the ERAS and the conventional groups did not have a normal distribution in terms of age. The age (years) group in ERAS ranged from 18 to 72 years while in the conventional care group it was from 22 to 80 years. There was a significant difference between the two groups in terms of age (W = 952.500, p = 0.040), with the median age being highest in the conventional group, that is, 45 years ([Table 3]). Eighteen out of 37 patients diagnosed with acute intestinal obstruction were managed with ERAS protocols while 19 were managed with conventional care protocol. Thirty-two out of 63 patients diagnosed with intestinal perforation were managed under ERAS protocols while 31 patients were managed with conventional care protocols ([Table 4]). The surgical outcome of the patients was calculated under the primary and secondary outcomes.
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Abbreviations: ERAS, enhanced recovery after surgery; IQR, interquartile range; SD, standard deviation.
Abbreviations: AIO, Acute intestinal obstruction; ERAS, enhanced recovery after surgery.
Analysis of Primary Outcome
The primary outcomes considered in our study were the LOS, perioperative morbidity, and mortality.
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Duration of hospital stay: A total of 96 patients were evaluated as 4 patients deceased during the postoperative course of hospital stay. The mean (standard deviation [SD]) of the duration of hospital stay in the ERAS group was 5.56 (4.55) days while in the conventional care group it was 8.75 (5.37) days. There was a significant difference between the two groups in terms of duration of hospital stay (W = 323.000, p ≤ 0.001), with the median duration being highest in the conventional care group, that is; 7 days ([Table 5]).
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Postoperative morbidities: These were paralytic ileus, postoperative nausea and vomiting, pulmonary complications, and SSIs (both superficial and deep).
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Pulmonary complications/chest infections: There was a significant difference seen between the two groups in terms of occurrence of pulmonary complications (χ2 = 4.828, p = 0.028), with the rate being more in the conventional group ([Table 5]).
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Paralytic ileus: Ninety-nine patients were evaluated for the occurrence of postoperative ileus which showed a significant difference between both the groups (χ2 = 4.966, p = 0.026). A total of 8.0% of the participants in the ERAS group had paralytic ileus as compared with 24.5% of the participants in the conventional care group ([Table 6]).
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Postoperative nausea and vomiting (PONV): Multimodal postoperative nausea and vomiting (PONV) prophylaxis was given to patients in the ERAS group and the outcomes were studied; no significant difference was seen between the two groups in terms occurrence of PONV (χ2 = 1.960, p = 0.204) ([Table 6]).
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Surgical site infections (SSIs): There was a significant difference between the two groups in terms of the distribution of SSIs (χ2 = 5.880, p = 0.015), with the conventional group having a larger proportion of SSIs ([Table 6]).
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Perioperative mortality: Both the ERAS group and the conventional care group were similar in terms of 30-day mortality risk (χ2 = 0.709, p = 0.678) ([Table 6]).
Group |
Statistical test |
||||
---|---|---|---|---|---|
Duration of hospital stay (days) (n = 96) |
ERAS |
Conventional |
W[a]/χ2b |
p -Value |
|
Mean (SD) |
5.56 (4.55) |
8.75 (5.37) |
323.000[a] |
< 0.001 |
|
Median (IQR) |
4 (1) |
7 (3) |
|||
Range |
3–27 |
4–32 |
|||
Chest infection (n = 99) |
Present |
7 (14.0%) |
16 (32.7%) |
4.828[b] |
0.028 |
Absent |
43 (86.0%) |
33 (67.3%) |
|||
Total |
50 (100.0%) |
49 (100.0%) |
Abbreviations: ERAS, enhanced recovery after surgery; IQR, interquartile range; SD, standard deviation.
a Wilcoxon test
b Chi-squared test
Group |
Statistical test |
|||||
---|---|---|---|---|---|---|
ERAS |
Conventional |
Total |
χ2 |
p-Value |
||
Paralytic Ileus (n = 99) |
Present |
4 (8.0%) |
12 (24.5%) |
16 (16.2%) |
4.966[a] |
0.026 |
Absent |
46 (92.0%) |
37 (75.5%) |
83 (83.8%) |
|||
Total |
50 (100.0%) |
49 (100.0%) |
99 (100.0%) |
|||
PONV (n = 99) |
Present |
1 (2.0%) |
4 (8.2%) |
5 (5.1%) |
1.960[b] |
0.204 |
Absent |
49 (98.0%) |
45 (91.8%) |
94 (94.9%) |
|||
Total |
50 (100.0%) |
49 (100.0%) |
99 (100.0%) |
|||
Surgical site infection (n = 98) |
Present |
18 (36.7%) |
30 (61.2%) |
48 (49.0%) |
5.880[a] |
0.015 |
Absent |
31 (63.3%) |
19 (38.8%) |
50 (51.0%) |
|||
Total |
49 (100.0%) |
49 (100.0%) |
98 (100.0%) |
|||
Mortality (n = 100) |
Present |
2 (4.0%) |
4 (8.0%) |
6 (6.0%) |
0.709[b] |
0.678 |
Absent |
48 (96.0%) |
46 (92.0%) |
94 (94.0%) |
|||
Total |
50 (100.0%) |
50 (100.0%) |
100 (100.0%) |
Abbreviations: ERAS, enhanced recovery after surgery; PONV, postoperative nausea and vomiting
a Chi-squared test
b Fisher's exact test
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Secondary Endpoints
The secondary endpoints that were considered for our study were the time to first flatus, the time elapsed until the resumption of oral feeding, the need for nasogastric tube reinsertion, the need for extra analgesics for pain relief, 30-day readmission, and re-exploration.
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Time to first flatus: The mean (SD) of day of passing flatus in the ERAS group was 1.78 (0.93) days while it was 2.51 (0.87) days in the conventional care group. The median (interquartile range [IQR]) of day of passing flatus in the ERAS group was similar to that of the conventional group, that is, 2 (1) days ([Table 7]). There was a significant difference between the two groups in terms of day of passing flatus (W = 633.000, p ≤ 0.001), with the mean day of passing flatus being highest in the conventional group, that is; 2.51 days ([Table 7]).
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Postoperative pain score and need for extra analgesia: The conventional care group in our study saw a significantly higher pain score and need for extra analgesia as compared with the ERAS group (W = 949.500, p = 0.048) ([Table 7]).
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Need for nasogastric tube reinsertion: These were similar in both the groups. (χ2 = 0.003, p = 1.000) ([Table 8]).
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Re-exploration rate: These were similar in both the groups (χ2 = 2.839, p = 0.160) ([Table 8]).
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Re-admission rate: There was no significant difference between the two groups in terms of 30-day re-admission rates (χ2 = 0.211, p = 1.000) ([Table 8]).
Abbreviations: ERAS, enhanced recovery after surgery; IQR, interquartile range; SD, standard deviation.
Abbreviations: ERAS, enhanced recovery after surgery; NG, nasogastric tube.
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Discussion
ERAS protocols have shown promising results in elective surgeries by greatly reducing the postoperative complications and causing early return of bowel function, thus reducing the LOS. But there is meager literature and research in case of emergency surgeries, owing to the assumption that the elements of ERAS cannot be applied to emergency settings. However, recent studies conclude otherwise and most of the elements can be included in emergency surgeries. We reported a reduced LOS along with reduced postoperative complications and faster recovery of bowel function. However, mortality rate, readmission, and re-exploration rates were similar for both groups. On reviewing the initial studies, we found a case-matched study by Lohsiriwat published in 2014 which included 60 patients divided into ERAS and non-ERAS groups in the ratio of 1:2 undergoing emergency resection for obstructive colorectal cancer.[7] He concluded a significantly shorter length of a hospital stay along with no difference in 30-day mortality and readmission rates which were similar to our study. However, he reported a nonsignificant reduction in the incidence of postoperative complications while our study showed a significant reduction in postoperative complications, especially postoperative ileus, SSIs, and pulmonary complications. This was one of the initial studies to establish the effectiveness and feasibility of ERAS protocols in the setting of emergency surgery. A randomized control trial performed by Gonenc et al in 2014 analyzed the feasibility of ERAS protocols in emergency laparoscopic surgery for perforated peptic ulcer and concluded similar results as our study.[8] It also negated the use of nasogastric tube for decompression and delayed oral feeding which was in itself a landmark. Wisely, in 2016, published a retrospective cohort study comparing 370 patients undergoing emergency abdominal surgeries for various diseases before and after the introduction of ERAS protocols and concluded that the ERAS group had significantly fewer patients who required catheters, drains, or postoperative analgesia for more than 2 days.[9] Major postoperative complications like urinary tract infections and chest infections were significantly reduced as was concluded by our study. However, in contrary to our study, Wisely concluded a similar duration of hospital stay in both the ERAS and non-ERAS groups. Another study by Shida et al in 2017 concluded that ERAS protocols resulted in a reduced median hospital stay by 3 days and a comparable rate of readmissions and mortality as concluded by our study, but, in contrast, also reported no significant reduction in postoperative complication rates.[10] In contrast to our study, Tengberg et al, in 2017, published a large single-center study including patients undergoing acute high-risk abdominal surgery and concluded a significant reduction in 30-day mortality rate in the intervention group (15.5% vs. 21.8% in the control group) and a 7.3% reduction in 180-day mortality.[11] Similar conclusion was obtained from the National Emergency Laparotomy Audit (NELA) that has been collecting data on all adult patients undergoing non–trauma-related emergency surgeries in NHS hospitals within England and Wales since 2013.[12] They also reported that since 2013, the national 30-day mortality rate in the United Kingdom has fallen from 11.8 to 9.5%. However, they also showed a reduction in LOS from 19.2 to 15.6 days while our study showed a reduction of hospital stay from 8.75 to 5.56 days. A systematic review published by Paduraru in 2017 showed a significant reduction in LOS by 2 to 3 days in two studies which were consistent with our study along with no effect on the mortality rates.[13] There was no significant increase in readmission rates in any of the studies which was also seen in our study. Shang et al, in 2018, did a multicenter study from China on 839 patients with obstructive colorectal cancer undergoing emergency laparotomy and concluded that the ERAS group had a significantly faster gastrointestinal recovery, fewer complications, and shorter LOS, which was also depicted in our study.[14] Lohsiriwat, in 2019, published another case-matched study where observed the clinical outcome of patients undergoing emergency colectomy and/or proctectomy with ERAS protocol from 2011 to 2017.[15] He observed a reduced LOS which was consistent with his previous study done in 2014 and also with our study. Also, strict adherence to ERAS protocol was associated with lower morbidity. Our study also showed similar results that were consistent with the results produced by a recent meta-analysis by Shahab Hajibandeh, published in January 2020, which compared 6 studies with 1,334 patients. He concluded that ERAS protocols resulted in the earlier return of bowel function and earlier resumption of oral feeds resulting in a shorter LOS. ERAS protocols also resulted in a lower rate of postoperative complications, mainly pulmonary complications, SSIs, and paralytic ileus, which was reciprocated in our study. Similar to our findings, the meta-analysis also concluded that the risk of 30-day mortality, readmissions, and re-exploration was the same in both the groups. This was the first meta-analysis that investigated the literature evaluating the ERAS protocols in emergency settings.[16]
Despite the studies depicting the success of ERAS, a recently published Enhanced Perioperative Care for High-Risk Patients (EPOCH) trial failed to demonstrate any of the results which were depicted in our study as well as the studies mentioned earlier.[17] It showed no significant difference in the LOS or readmission rate between the two groups.
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Conclusion
Tailored ERAS protocol is safe and effective in emergency surgery. However, validation of any study requires a repeated measurement of the endpoints which yield consistent values. We would suggest that if a standardized ERAS protocol specific for emergency surgeries could be developed, it would lead to a much better clinical outcome of the patient and also reduce the economic burden of a country due to high hospital costs because of the morbidity associated with these diseases.
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Conflict of Interest
None declared.
Acknowledgments
None.
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References
- 1 Jones EL, Wainwright TW, Foster JD, Smith JRA, Middleton RG, Francis NK. A systematic review of patient reported outcomes and patient experience in enhanced recovery after orthopaedic surgery. Ann R Coll SurgEngl 2014; 96 (02) 89-94
- 2 Shrime MG, Bickler SW, Alkire BC, Mock C. Global burden of surgical disease: an estimation from the provider perspective. Lancet Glob Health 2015; 3 (Suppl. 02) S8-S9
- 3 Williams NS, O'Connell PR, McCaskie AW. In: Bailey & Love’s short practice of surgery. 27th ed. Boca Raton, FL: CRC Press, Taylor & Francis Group; 2018: 4-8
- 4 Kehlet H, Wilmore DW. Evidence-based surgical care and the evolution of fast-track surgery. Ann Surg 2008; 248 (02) 189-198
- 5 Engelman DT, Ben Ali W, Williams JB. et al. Guidelines for perioperative care in cardiac surgery: enhanced recovery after surgery society recommendations. JAMA Surg 2019; 154 (08) 755-766
- 6 Gustafsson UO, Scott MJ, Schwenk W. et al; Enhanced Recovery After Surgery (ERAS) Society, for Perioperative Care, European Society for Clinical Nutrition and Metabolism (ESPEN), International Association for Surgical Metabolism and Nutrition (IASMEN). Guidelines for perioperative care in elective colonic surgery: Enhanced Recovery After Surgery (ERAS(®)) Society recommendations. World J Surg 2013; 37 (02) 259-284
- 7 Lohsiriwat V. Enhanced recovery after surgery vs conventional care in emergency colorectal surgery. World J Gastroenterol 2014; 20 (38) 13950-13955
- 8 Gonenc M, Dural AC, Celik F. et al. Enhanced postoperative recovery pathways in emergency surgery: a randomised controlled clinical trial. Am J Surg 2014; 207 (06) 807-814
- 9 Wisely JC, Barclay KL. Effects of an enhanced recovery after surgery programme on emergency surgical patients. ANZ J Surg 2016; 86 (11) 883-888
- 10 Shida D, Tagawa K, Inada K. et al. Modified enhanced recovery after surgery (ERAS) protocols for patients with obstructive colorectal cancer. BMC Surg 2017; 17 (01) 18
- 11 Tengberg LT, Bay-Nielsen M, Bisgaard T, Cihoric M, Lauritsen ML, Foss NB. AHA study group. Multidisciplinary perioperative protocol in patients undergoing acute high-risk abdominal surgery. Br J Surg 2017; 104 (04) 463-471
- 12 The National Emergency Laparotomy Audit Web site. www.nela.org.uk . Accessed January 18, 2021
- 13 Paduraru M, Ponchietti L, Casas IM. et al. Enhanced recovery after surgery (ERAS)—the evidence in geriatric emergency surgery: a systematic review. Chirurgia (Bucur) 2017; 112 (05) 546-557
- 14 Shang Y, Guo C, Zhang D. Modified enhanced recovery after surgery protocols are beneficial for postoperative recovery for patients undergoing emergency surgery for obstructive colorectal cancer: a propensity score matching analysis. Medicine (Baltimore) 2018; 97 (39) e12348
- 15 Lohsiriwat V. Enhanced recovery after surgery for emergency colorectal surgery: are there any differences between intra-abdominal infection and other indications?. J ViscSurg 2019; 156 (06) 489-496
- 16 Hajibandeh S, Hajibandeh S, Bill V, Satyadas T. Meta-analysis of enhanced recovery after surgery (ERAS) protocols in emergency abdominal surgery. World J Surg 2020; 44 (05) 1336-1348
- 17 Peden CJ, Stephens T, Martin G. et al; Enhanced Peri-Operative Care for High-risk patients (EPOCH) trial group. Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery (EPOCH): a stepped-wedge cluster-randomised trial. Lancet 2019; 393 (10187): 2213-2221
Address for correspondence
Publikationsverlauf
Eingereicht: 29. September 2020
Angenommen: 30. Dezember 2020
Artikel online veröffentlicht:
03. Juni 2021
© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
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References
- 1 Jones EL, Wainwright TW, Foster JD, Smith JRA, Middleton RG, Francis NK. A systematic review of patient reported outcomes and patient experience in enhanced recovery after orthopaedic surgery. Ann R Coll SurgEngl 2014; 96 (02) 89-94
- 2 Shrime MG, Bickler SW, Alkire BC, Mock C. Global burden of surgical disease: an estimation from the provider perspective. Lancet Glob Health 2015; 3 (Suppl. 02) S8-S9
- 3 Williams NS, O'Connell PR, McCaskie AW. In: Bailey & Love’s short practice of surgery. 27th ed. Boca Raton, FL: CRC Press, Taylor & Francis Group; 2018: 4-8
- 4 Kehlet H, Wilmore DW. Evidence-based surgical care and the evolution of fast-track surgery. Ann Surg 2008; 248 (02) 189-198
- 5 Engelman DT, Ben Ali W, Williams JB. et al. Guidelines for perioperative care in cardiac surgery: enhanced recovery after surgery society recommendations. JAMA Surg 2019; 154 (08) 755-766
- 6 Gustafsson UO, Scott MJ, Schwenk W. et al; Enhanced Recovery After Surgery (ERAS) Society, for Perioperative Care, European Society for Clinical Nutrition and Metabolism (ESPEN), International Association for Surgical Metabolism and Nutrition (IASMEN). Guidelines for perioperative care in elective colonic surgery: Enhanced Recovery After Surgery (ERAS(®)) Society recommendations. World J Surg 2013; 37 (02) 259-284
- 7 Lohsiriwat V. Enhanced recovery after surgery vs conventional care in emergency colorectal surgery. World J Gastroenterol 2014; 20 (38) 13950-13955
- 8 Gonenc M, Dural AC, Celik F. et al. Enhanced postoperative recovery pathways in emergency surgery: a randomised controlled clinical trial. Am J Surg 2014; 207 (06) 807-814
- 9 Wisely JC, Barclay KL. Effects of an enhanced recovery after surgery programme on emergency surgical patients. ANZ J Surg 2016; 86 (11) 883-888
- 10 Shida D, Tagawa K, Inada K. et al. Modified enhanced recovery after surgery (ERAS) protocols for patients with obstructive colorectal cancer. BMC Surg 2017; 17 (01) 18
- 11 Tengberg LT, Bay-Nielsen M, Bisgaard T, Cihoric M, Lauritsen ML, Foss NB. AHA study group. Multidisciplinary perioperative protocol in patients undergoing acute high-risk abdominal surgery. Br J Surg 2017; 104 (04) 463-471
- 12 The National Emergency Laparotomy Audit Web site. www.nela.org.uk . Accessed January 18, 2021
- 13 Paduraru M, Ponchietti L, Casas IM. et al. Enhanced recovery after surgery (ERAS)—the evidence in geriatric emergency surgery: a systematic review. Chirurgia (Bucur) 2017; 112 (05) 546-557
- 14 Shang Y, Guo C, Zhang D. Modified enhanced recovery after surgery protocols are beneficial for postoperative recovery for patients undergoing emergency surgery for obstructive colorectal cancer: a propensity score matching analysis. Medicine (Baltimore) 2018; 97 (39) e12348
- 15 Lohsiriwat V. Enhanced recovery after surgery for emergency colorectal surgery: are there any differences between intra-abdominal infection and other indications?. J ViscSurg 2019; 156 (06) 489-496
- 16 Hajibandeh S, Hajibandeh S, Bill V, Satyadas T. Meta-analysis of enhanced recovery after surgery (ERAS) protocols in emergency abdominal surgery. World J Surg 2020; 44 (05) 1336-1348
- 17 Peden CJ, Stephens T, Martin G. et al; Enhanced Peri-Operative Care for High-risk patients (EPOCH) trial group. Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery (EPOCH): a stepped-wedge cluster-randomised trial. Lancet 2019; 393 (10187): 2213-2221
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