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Synfacts 2021; 17(11): 1283
DOI: 10.1055/s-0040-1720903
DOI: 10.1055/s-0040-1720903
Peptide Chemistry
Allenone-Mediated Formation of Peptide Bonds
Wang Z,
Wang X,
Wang P,
Zhao J.
*
Guangzhou Medical University, Northwestern Polytechnical University, Xi’an, Jiangxi Normal University, Nanchang, and Nankai University, Tianjin, P. R. of China
Allenone-Mediated Racemization/Epimerization-Free Peptide Bond Formation and Its Application in Peptide Synthesis.
J. Am. Chem. Soc. 2021;
143: 10374-10381
DOI: 10.1021/jacs.1c04614.
Allenone-Mediated Racemization/Epimerization-Free Peptide Bond Formation and Its Application in Peptide Synthesis.
J. Am. Chem. Soc. 2021;
143: 10374-10381
DOI: 10.1021/jacs.1c04614.
Significance
The development of an efficient method for amide bond formation is important in peptide drug discovery. The authors have developed an allenone-mediated peptide synthesis.
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Comment
This allenone-mediated amidation reaction affords peptides containing a variety of amino acid residues in high yields without any epimerization.
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Publication History
Article published online:
19 October 2021
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