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Synfacts 2021; 17(12): 1403
DOI: 10.1055/s-0040-1720005
DOI: 10.1055/s-0040-1720005
Peptide Chemistry
Peptide Synthesis by Asymmetric Transamination of α-Keto Amides
Cai W,
Qiao X,
Zhang H,
Li B,
Guo J,
Zhang L,
Chen W.-W,
Zhao B.
*
Shanghai Normal University, P. R. of China
Asymmetric Biomimetic Transamination of α-Keto Amides to Peptides.
Nat. Commun. 2021;
12
DOI: 10.1038/s41467-021-25449-y.
Asymmetric Biomimetic Transamination of α-Keto Amides to Peptides.
Nat. Commun. 2021;
12
DOI: 10.1038/s41467-021-25449-y.
Significance
Peptide synthesis is important in drug discovery and medicinal chemistry. The authors have developed an asymmetric transamination method for synthesizing peptides from α-keto amides.
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Comment
By using an N-quaternized axially chiral pyridoxamine as a catalyst, a wide range of dipeptides can be synthesized from α-keto amides in good to excellent yields. This transamination method can also be applied in peptide elongation to synthesize peptide chains containing unnatural amino acids.
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Publication History
Article published online:
17 November 2021
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