RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000131.xml
Synfacts 2021; 17(12): 1411
DOI: 10.1055/s-0040-1720002
DOI: 10.1055/s-0040-1720002
Peptide Chemistry
Propargyl Pentafluorophenyl Carbonate as a Coupling Reagent for Peptide Synthesis
Bhat RG,
Kérourédan E,
Porhiel E,
Chandrasekaran S.
*
Indian Institute of Science, Bangalore, India
Synthesis and Applications of Propargyl Pentafluorophenyl Carbonate for Peptide Synthesis.
Tetrahedron Lett. 2002;
43: 2467-2469
DOI: 10.1016/S0040-4039(02)00287-3.
Synthesis and Applications of Propargyl Pentafluorophenyl Carbonate for Peptide Synthesis.
Tetrahedron Lett. 2002;
43: 2467-2469
DOI: 10.1016/S0040-4039(02)00287-3.
![](https://www.thieme-connect.de/media/synfacts/202112/i_h110_s1_10-1055_s-0040-1720002.gif)
Significance
Developing new coupling reagents that are efficient, sustainable, reduce the number of reaction steps, and minimize waste production is a significant topic in peptide chemistry. In 2002, Chandrasekaran and co-workers invented propargyl pentafluorophenyl carbonate (Poc-OPfp), an efficient reagent for synthesizing N-propargyl amino acids, and described its application in peptide synthesis.
#
Comment
Poc-OPfp was synthesized by the reaction of propargyl chloroformate with pentafluorophenol and used for the synthesis of various N-Poc amino acids and peptides in excellent yields.
#
#
Publikationsverlauf
Artikel online veröffentlicht:
17. November 2021
© 2021. Thieme. All rights reserved
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
![](https://www.thieme-connect.de/media/synfacts/202112/i_h110_s1_10-1055_s-0040-1720002.gif)