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Synfacts 2021; 17(12): 1411
DOI: 10.1055/s-0040-1720002
DOI: 10.1055/s-0040-1720002
Peptide Chemistry
Propargyl Pentafluorophenyl Carbonate as a Coupling Reagent for Peptide Synthesis
Bhat RG,
Kérourédan E,
Porhiel E,
Chandrasekaran S.
*
Indian Institute of Science, Bangalore, India
Synthesis and Applications of Propargyl Pentafluorophenyl Carbonate for Peptide Synthesis.
Tetrahedron Lett. 2002;
43: 2467-2469
DOI: 10.1016/S0040-4039(02)00287-3.
Synthesis and Applications of Propargyl Pentafluorophenyl Carbonate for Peptide Synthesis.
Tetrahedron Lett. 2002;
43: 2467-2469
DOI: 10.1016/S0040-4039(02)00287-3.
Significance
Developing new coupling reagents that are efficient, sustainable, reduce the number of reaction steps, and minimize waste production is a significant topic in peptide chemistry. In 2002, Chandrasekaran and co-workers invented propargyl pentafluorophenyl carbonate (Poc-OPfp), an efficient reagent for synthesizing N-propargyl amino acids, and described its application in peptide synthesis.
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Comment
Poc-OPfp was synthesized by the reaction of propargyl chloroformate with pentafluorophenol and used for the synthesis of various N-Poc amino acids and peptides in excellent yields.
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Publication History
Article published online:
17 November 2021
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