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Synfacts 2021; 17(10): 1169
DOI: 10.1055/s-0040-1719972
DOI: 10.1055/s-0040-1719972
Peptide Chemistry
Synthesis of a Side-Chain-Tethered Solid Support for Peptide Synthesis
Lee Y,
Silverman RB.
*
Northwestern University, Evanston, USA
Traceless Solid-Phase Synthesis of Chiral 3-Aryl β-Amino Acid Containing Peptides Using a Side-Chain-Tethered β-Amino Acid Building Block.
Org. Lett. 2000;
3: 303-306
DOI: 10.1021/ol9912480.
Traceless Solid-Phase Synthesis of Chiral 3-Aryl β-Amino Acid Containing Peptides Using a Side-Chain-Tethered β-Amino Acid Building Block.
Org. Lett. 2000;
3: 303-306
DOI: 10.1021/ol9912480.
Significance
Silicon-linked solid supports play a major role in peptide syntheses because of the ease with which silicon-based linkers can be attached and detached. In 2000, Lee and Silverman developed silicon-linked side-chain-tethered β-amino acid building blocks for peptide synthesis.
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Comment
The silicon-linked side-chain-tethered β-amino acid building blocks were synthesized in good yields. The synthesized support permits the elongation of a peptide chain at both its C-terminal and N-terminal directions. Furthermore, it can be used for the synthesis of 3-aryl-β-alanine-containing tripeptides in good yields.
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Publication History
Article published online:
17 September 2021
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