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DOI: 10.1055/s-0040-1715483
Extracardiac Complications in Intensive Care Units after Surgical Repair for Congenital Heart Disease: Imaging Review with a Focus on Ultrasound and Radiography
- Abstract
- Introduction
- Classification Based on the Location of the Extracardiac Organ
- Approach Methods Using Ultrasound for Various Complications
- Timing of Examination
-
Locations and Types of Complications: Intrathoracic and Diaphragmatic Complications
-
Locations and Types of Complications: Intra-abdominal and Other Locations' Complications
- Conclusion
- References
Abstract
Pediatric patients show various extracardiac complications after cardiovascular surgery, and radiography and ultrasound are routinely performed in the intensive care unit to detect and evaluate these complications. This review presents images of these complications, sonographic approach, and timing of occurrence that are categorized based on their extracardiac locations and include complications pertaining to the central nervous system, mediastinum, thorax and lung parenchyma, diaphragm, liver and biliary system, and kidney along with pleural effusion and iatrogenic complications. This pictorial review will make it easier for medical doctors in intensive care units to identify and manage various extracardiac complications in pediatric patients after cardiovascular surgery.
#
Introduction
Various extracardiac complications have been reported in pediatric patients after cardiovascular surgery.[1] These patients should receive early and appropriate interventions to prevent a prolonged stay in the intensive care unit.[2] [3] [4] Radiography and ultrasound are routinely performed at patients' bedside by pediatric physicians, cardiologists, intensivists, or radiologists to detect these complications and evaluate the patients' condition while they are admitted to the intensive care unit.[3] [5] [6] [7]
To the best of our knowledge, although some previous reports have focused on the risk factors for the occurrence of these complications and their prognosis, there are no reports focusing on the image findings of these complications. The purpose of this review is to show the image findings of these complications using radiography and ultrasound.[2] [8] [9] [10] This pictorial review will help doctors in intensive care units to more easily identify and manage various extracardiac complications in pediatric patients after cardiovascular surgery.
#
Classification Based on the Location of the Extracardiac Organ
The extracardiac complications occurring after cardiovascular surgery are classified based on the locations of occurrence. [Tables 1] and [2] show locations and types of these complications ([Table 1]: locations and types of complications and intrathoracic and diaphragmatic complications, and [Table 2]: locations and types of complications and intra-abdominal and other locations' complications). Although their incidence and timing of onset vary depending on the underlying congenital heart diseases, treatments or institutions' comprehensive data pertaining to these complications are important for daily management and evaluation of pediatric patients after cardiovascular surgery in the intensive care unit.
Location |
Types |
Incidence (number of occurrence/total number) |
Interval between surgery and diagnosis average ± SD (range) |
Comments |
Ref. |
---|---|---|---|---|---|
Mediastinum |
Hemorrhage/hematoma |
10% (6/54) |
[115] |
||
N/A |
16 (12–22) days |
3 cases |
[9] |
||
4.1% (5/121) |
Only patients who underwent mechanical aortic valve replacement were included |
[116] |
|||
N/A |
1 and 10 days |
2 cases |
[12] |
||
11–40% |
Variable bleeding rate depending on the implanted durable devices |
[117] |
|||
SSI |
2.2% (9/412) 5.8% (24/412) |
Organ/space infection DII or SWI |
[2] |
||
2.4% (27/1,117) 0.1% (1/1,117) 0.9% (10/1,117) |
Organ/space infection DII SWI |
[118] |
|||
0.8% (7/826) 1.5% (12/826) |
Organ/space infection DII and SWI |
[119] |
|||
N/A |
17.2 (6–30) days 5 and 10 days |
6 cases with DII and SWI 2 cases with organ/space infection |
[120] |
||
6.3% (384/6,127) 1.8% (107/6,127) |
Wound infection with delayed sternal closure Mediastinitis with delayed sternal closure |
[121] |
|||
Mediastinitis (organ/space infection) |
1.1% (29/2,675) |
10 (5–27) days |
[122] |
||
N/A |
27.3 (7–53) days |
[9] |
|||
0.2% (17/7,616) |
14 (6–50 days) days |
[18] |
|||
0.85% (57/6,705) |
13 days |
[123] |
|||
5% (10/202) |
[124] |
||||
1.4% (19/1,405) |
32 days (5 days–9 months) |
[125] |
|||
1.7% (64/3,650) |
13.4 (4–37) days |
[126] |
|||
8.3% (3/36) |
8.8 (5–14) days |
Only neonate (under 4 weeks of age) were included |
[127] |
||
Pleural effusion |
Pleural effusion |
N/A |
|||
Hemothorax |
N/A |
||||
Chylothorax |
5% (57/1,135) |
0–10 days |
[23] |
||
5% (12/238) |
Chylothorax or plastic bronchitis. All cases with Fontan procedure were included. |
[30] |
|||
Thorax |
Pneumothorax |
N/A |
|||
Lug parenchyma |
Atelectasis |
N/A |
|||
Lung infection |
Pneumonia Respiratory infection upper Respiratory infection lower |
0.7% (3/412) 1.7% (7/412) 0.5% (2/412) |
[2] |
||
Diaphragm |
Diaphragmatic paralysis |
1.5% (25/1,656) |
Plication rate was 44%, and the procedure was performed 2–3 weeks after operation |
[128] |
|
0.46% (47/10,200) |
Plication rate was 79%, and the procedure was performed 24 ± 14 days after the operation |
[41] |
|||
2.1% (19/891) |
Plication rate was 79% |
[40] |
|||
4.9% (152/3,071) |
Plication rate was 1.3%, and the procedure was performed 17.8 ± 3.6 days after the operation |
[39] |
|||
4.8% (24/500) |
Plication was performed in all cases |
[129] |
Abbreviations: DII, deep incisional infection; N/A, not available; Ref., reference; SD, standard deviation; SSI, surgical site infection; SWI, superficial wound infection.
Location |
Types |
Incidence (number of occurrence/total number) |
Interval between surgery and diagnosis average ± SD (range) |
Comments |
Ref. |
---|---|---|---|---|---|
CNS |
IVH Cerebral infarction |
0.9% (5/543) 1.7% (9/543) |
[49] |
||
IVH |
17% (6/34) |
4 hours after the surgery (routine examination) |
Arterial switch operation in neonates |
[50] |
|
Subdural hemorrhage |
0.1% (1/706) |
[47] |
|||
Liver and biliary system |
Acute liver failure (liver insufficiency) |
15% (8/54) |
This study focused on the NEC. Neonates with and without NEC were included. |
[70] |
|
Debris within biliary system |
N/A |
19th day |
Case report |
[130] |
|
Intestine |
NEC |
11% (8/73) |
[70] |
||
18% (9/43) |
Hypoplastic left heart syndrome |
[68] |
|||
13% (14/108) 12% (8/66) 14% (7/50) |
25 ± 17 (days of life) 36 ± 19 (days of life) 22 ± 15 (days of life) |
Indomethacin (performed 4 ± 3 days of life) Indomethacin and ligation (11 ± 8 days of life) Ligation (9 ± 13 days of life) Treatment for PDA in premature neonates; |
[73] |
||
11.0% (8/65) 5.8% (3/49) |
Only neonates performed the Norwood procedure were included and using different protocol of enteral feeding |
[131] |
|||
14/52 (27%) 3/46 (6.5%) |
Hypoplastic left heart syndrome after the Norwood procedure and using different protocol of enteral feeding |
[71] |
|||
N/A |
21 postoperative hours (1 case) 1 postoperative day (2 cases) |
3 cases reports |
[69] |
||
1.7% (19/1120) |
[67] |
||||
Paradoxical hypertension result in postcoarctectomy syndrome or mesenteric arteritis |
56% (14/25) |
After repair of coarctation of the aorta |
[86] |
||
6% (9/145) |
4 (3–6) days |
After repair of coarctation of the aorta |
[72] |
||
Gastroenteritis |
0.08% (1/1120) |
[67] |
|||
Kidney |
AKI |
90% (53/59) |
Using ECMO during cardiovascular surgery |
[132] |
|
54% (352/613) |
2 (1–6) days |
AKI remained stable until 4th postoperative days |
[133] |
||
62% (76/122) |
Progression of AKI within 48 hours after surgery |
Only neonates were included |
[8] |
||
35% (33/125) |
1 postoperative day in 57% of cases (1–27 days) |
Most cases resolved within 24 hours (65% of cases) |
[94] |
||
26% (51/194) 14% (28/201) |
<2 years ≥2years |
[134] |
|||
17% (53/311) |
Sever AKI (receipt of acute dialysis) |
[137] |
|||
51% (234/458) |
Usually within 48 hours after surgery |
[135] |
|||
UTI |
3.6% (15/412) |
[2] |
|||
Vascular complication[a] |
Phlebitis associated PICC[a] |
13% (83/654) |
86 hours (12–286 hours after insertion) |
[105] |
|
Venous thromboembolism |
2% (65/2,718) |
[136] |
|||
Thrombosis |
15% (8/53) 16% (6/37) |
4.8 ± 3.7 days 5.1 ± 3.6 days |
With heparin With placebo |
[106] |
Abbreviations: AKI, acute kidney injury; CNS, central nervous system; ECMO, extracorporeal membrane oxygenation; IVH; Intraventricular hemorrhage; N/A, not available; NEC, necrotizing enterocolitis; PDA, patent ductus arteriosus; PICC, peripheral inserted central catheter; SD, standard deviation; UTI, urinary tract infection.
a Catheter-associated complications: there were no previous reports focusing on pediatric patients after cardiovascular surgery; therefore, these incidences were reported from studies targeting pediatric patients.
#
Approach Methods Using Ultrasound for Various Complications
In clinical settings, abdominal or cardiac ultrasound is usually performed, whereas in intensive care units, ultrasound is performed for various sites ([Fig. 1]). The approach for nonfamiliar sites may differ across physicians; therefore, a schematic guideline to demonstrate the approach methods for nonfamiliar target organs, such as the cranium, trachea, mediastinum, lungs, and diaphragm, is necessary.[3] [11] [12] [13] [14] [15] Vascular complications can be found at any location; hence, point-of-care ultrasound is useful.
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Timing of Examination
In the guideline for after surgical repair for congenital heart disease, if a change in clinical status or new concerning signs or symptoms are detected, computed tomography (CT) and radiography could be recommended.[16] In the guideline, however, transesophageal echocardiogram is included but ultrasound targeting the abdomen or other organs is not included.[16] The timing of examination could be varied based on the kinds of complication and of modality used for the diagnosis. Therefore, the timing of occurrence of each complication and strategy, including the modality for diagnosing the complications, was stated in each below section of complications.
#
Locations and Types of Complications: Intrathoracic and Diaphragmatic Complications
Mediastinum
Information regarding mediastinal complications, including surgical site infection (mediastinitis) and hemorrhage, is important to ensure appropriate intervention ([Table 1]).
#
Timing of Occurrence and Strategy for the Diagnosis
The complications in the mediastinum include hemorrhage or surgical site infection. Mediastinal hemorrhage usually occurs within 1 week after intrathoracic surgery.[9] [17] [18] [19] The surgical site infection (organ/space infection [mediastinitis]) usually occurs 1 week after intrathoracic surgery.[9] [17] [18] [19] Computed tomography is reported to be a useful modality for diagnosing mediastinitis; however, this modality requires radiation exposure and cannot be performed at a patient's bedside; ultrasound is reported to be useful for diagnosing mediastinitis.[5] [12] [20] If the circulation status is stable to undertake the ultrasound, ultrasound is used to detect the retrosternal fluid correction at the patients' bedsides. If fluid correction is detected, further examinations, such as CT, were recommended.[9] [12] [19] Color Doppler ultrasound is useful for evaluating the intrathoracic structure and differentiating a pseudoaneurysm from the fluid correction.[5] [12]
-
Mediastinal hematoma/hemorrhage: Hematoma or bleeding at the surgical site is a critical complication during and after surgical procedures, and it is a common complication that requires reoperation.[1] Hematoma results in an unstable circulation status, necessitating rapid surgical intervention. Management of hematomas may be difficult and should be based on each patient's condition. In addition to vital sign and laboratory data, image findings may be useful to diagnose this complication ([Fig. 2]).[12]
-
Surgical site infection (incisional or organ/space [mediastinitis]): surgical site infection is classified into following three types based on the depth of the infection: (1) superficial wound infection, (2) deep incisional infection, and (3) organ/space infection. Mediastinitis is classified as an organ/space infection, and it causes critical complications, has a high mortality rate, and requires adequate surgical intervention ([Figs. 3] and [4]).[2] [9]
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#
Sonographic Evaluation
Ultrasound was recently reported to be useful in the evaluation of mediastinitis.[5] [12] Retrosternal fluid collection and parasternal hyperechogenicity are usually detected in cases of mediastinitis.[12] [19] Superficial wound infection and deep incisional infection are detected as parasternal or subcutaneous hyperechogenicity ([Fig. 3]), and organ/space infection is detected as retrosternal fluid collection ([Fig. 4]).[5] [12] Although these findings have high–negative predictive value for diagnosing mediastinitis, cases with hematoma may show these findings ([Fig. 2]).[9] [12] [19] In addition, Hosokawa et al reported that the two cases with mediastinitis having retrosternal simple fluid correction.[12] There are various CT reports that the cases with mediastinitis had various degree of enhancement and various timing when the mediastinitis occurred.[9] [17] [19] Echogenicity within the retrosternal fluid correction might be varied based on the degree of inflammation, period between the examination and onset of mediastinitis, and treatment before the examination.
#
Pleural Effusion, Thorax, and Lung Parenchyma
Atelectasis, pneumonia, or pleural effusion associated with mechanical ventilation may occur in pediatric patients after cardiovascular surgery.[2] These complications are caused by mechanical support modalities such as ventilation or extracorporeal membrane oxygenation (ECMO).[21] Lung ultrasound is typically used to evaluate these complications in intensive care units.[6] [22]
#
Timing of Occurrence and Strategy for Diagnosis
Hemothorax or atelectasis may occur during operation or in the intensive care unit. After ECMO, lung opacity for lung rest usually occurred within 24 hours, and may last only a few days or as long as 4 to 6 weeks depending on the patients' pulmonary condition.[21] The duration between thoracic duct injury and development of chylothorax is usually 0 to 10 days.[23] Pleural effusion is diagnosed by combination of clinical symptom, radiography, and ultrasound. Based on the species of pleural effusion, further recommended examination is changed. If the chylothorax suspected, lymphoscintigraphy is usually recommended.[24] [25] [26]
1. Pleural effusion without or with complex echogenicity
Pleural effusion is commonly observed after cardiovascular surgery. Ultrasound is a useful modality to evaluate the characteristics of this effusion ([Figs. 5] and [6]).[6] [22]
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Sonographic Evaluation
The echogenicity within the effusion is different for the varying etiologies of pleural effusion.[27] Transudative pleural effusion is anechoic ([Fig. 5]), while exudative pleural effusion showed septation or nonseptation and is anechoic.[27] Hemothorax occurs frequently after cardiovascular surgery. Blood in the pleural cavity shows a complex echogenicity, including hyper- to low-echoic density ([Fig. 6]).[28] [29]
2. Chylothorax
Chylothorax refers to the accumulation of the chyle in the pleural cavity that usually develops after disruption of the thoracic duct during intrathoracic surgery ([Fig. 7]).[23] Chylothorax after cardiovascular surgery is a not-so-rare complication and is related to the duration of hospitalization.[23] [30] Various modalities, such as lymphoscintigraphy, lymphangiography, and magnetic resonance lymphography, have been used to evaluate this condition and select appropriate treatment.[24] [25] [26] However, traumatic events resulting in chylothorax are usually obvious, minor surgical trauma has also been noted to result in chylothorax. Therefore, the lymphoscintigraphy procedure is important for diagnosing chylothorax. This examination is easy compared with lymphangiography because it is performed only after injection of 99 mTc-HAS-DTPA into the subcutaneous tissue of the bilateral dorsum pedis.[31] [32] The first treatment usually was total parenteral nutrition instead of the nutrition per mouth until chyle drainage decreases. Octreotide intravenous infusion is added in patients who do not show a response to these treatments.[23] In cases showing no response to conservative treatment, including surgical ligation, lymphatic-venous anastomosis, and embolization at the leakage, point system might be performed.[23] [24] [33]
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3. Pneumothorax
Pneumothorax can be demonstrated or excluded with a high degree of accuracy using ultrasound ([Figs. 8] and [9]).[6] [22] Artifacts, such as the comet-tail sign or bands, of reverberating echoes are normally seen at the junction of the pleura and the ventilated lung.[6] [22]
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Sonographic Evaluation
The detection of lung point, which represents the physical limit of pneumothorax, is important to diagnose the pneumothorax ([Fig. 8]).[34] The area with absence of lung sliding or movement of B-line, that is, comet tail–like artifact extending from pleural line to the bottom of the screen obliterating, is the area of affected pneumothorax ([Figs. 8] and [9]).[34] [35]
4. Atelectasis
Lung atelectasis is a common finding in the intensive care unit. Aspiration, prolonged bed rest, or iatrogenic factors may result in the atelectasis. In addition, atelectasis caused by lung rest usually occurs after ECMO ([Fig. 10]).[21] In patients undertaken the ECMO, the lungs show progressive opacification on radiograph. The etiology of these changes is unclear, but multifactor, such as varying degrees of widespread atelectasis and pulmonary edema, was influenced.[21] [36] Lung ultrasound was reported to be able to differentiate the atelectasis, lung edema, and pleural effusion.[6] [11] [22] [34] Therefore, ultrasound may be useful morality to evaluate the lung status after ECMO.
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Sonographic Evaluation
Lung aeration can be classified as well aerated, partially aerated, or completely deaerated.[35] [37] The well-aerated lung is seen as A-line; this is seen as parallel lines in the intercostal space that descend to the bottom of the screen ([Fig. 9]). Dynamic sliding of the pleura is clearly detected in real time. The partially aerated lung is seen as B-line; this is seen as a comet tail–like artifact, extending from the pleural line to the bottom of the screen ([Fig. 8]). Increased numbers of B-line are seen in interstitial lung disease or edema.[37] [38] The deaerated lung, as in lung consolidation, has a shredding appearance on the air bronchogram ([Fig. 10]).
#
Diaphragm
Phrenic Nerve Paralysis
Timing of Occurrence and Strategy for Diagnosis
Phrenic nerve paralysis may occur during surgery. Surgical treatment, such as diaphragmatic plication, is usually performed at least 2 weeks after operation.[39] [40] [41] This complication is suspected in routine radiograph and ultrasound is usually recommended to evaluate the motion of diaphragm.[3] [13] [22] [39] [42] While fluorography is also a useful morality to diagnose this complication, this procedure cannot be performed at a patient's bedside.[42]
Phrenic nerve paralysis after cardiovascular surgery is associated with prolonged hospitalization ([Fig. 11]).[39] Radiographic findings showing the differences on each side of the diaphragm are important to suspect the presence of phrenic nerve paralysis.[42] Based on this suspicion, movement of the diaphragm is evaluated using ultrasound or fluorography.[3] [13] [22] [39] [42] M-mode ultrasonography in a longitudinal view of the diaphragm is performed by positioning the probe on the posterior axillary line on one side with the transducer notch pointing 12 o'clock toward axilla.[3] Paradoxical movement of the diaphragm or weak movement of the affected diaphragm is observed in cases with this complication.[39] [43]
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Sonographic Evaluation
Normal movement of the diaphragm is defined as movement toward the transducer during inspiration with an excursion of more than 4 mm and a difference of less than 50% between the movements of the two hemidiaphragms ([Fig. 11]). Paretic movement is defined as an amplitude of less than 4 mm and a difference of more than 50% between the movements of the two hemidiaphragms. Paradoxical movement is defined as diaphragmatic movement away from the transducer during inspiration ([Videos 1] and [2]; available in the online version).[3] [44] [45]
Video 1 The position of the left diaphragm is unchanged during inspiration and expiration. The right diaphragm demonstrates normal movement. The descending aorta is located more toward the right during expiration than during inspiration. Therefore, paradoxical movement of diaphragm was diagnosed. Ao, descending aorta.
Quality:
Video 2 Fluoroscopic examination of the diaphragm. The right normal hemidiaphragm descends with inspiration. The left hemidiaphragm demonstrates paradoxical upward movement with inspiration. The mediastinum is located more toward the right during expiration than during inspiration.
Quality:
#
#
Locations and Types of Complications: Intra-abdominal and Other Locations' Complications
Central nervous System
The incidence of acute neurologic complications after cardiovascular surgery in pediatric patients is reported to be 2 to 25%.[46] [47] Although the anterior fontanelle typically closes between the ages of 12 and 18 months, ultrasound via the fontanelle is useful to evaluate hemorrhage ([Table 2]).[48]
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Timing of Occurrence and Strategy for Diagnosis
Central nervous system complications are associated with hypoperfusion, cardiac arrest, or thromboembolism, or treatment such as anticoagulant therapy.[46] [47] [49] Therefore, these complications may be encountered during cardiovascular surgery. Intracranial hemorrhage can be found 4 hours postoperatively using ultrasound.[50] However, cranial ultrasound is useful to diagnose this complication, in case with after closure of the anterior fontanelle, CT, or magnetic resonance imaging is needed to diagnose this complication.[51] Magnetic resonance imaging does not have need of radiation exposure, but it needs the relative longer time for examination compared the CT. The values of the resistive index, peak systolic, end diastolic, and time-averaged velocities of intracranial artery are determined by using Doppler techniques, and that is useful for the diagnosis, follow-up, and management of brain damage.[52] [53]
-
Hemorrhage: hemorrhage is associated with anticoagulant therapy or prematurity ([Fig. 12]).[47] [48] Ultrasound via the anterior fontanelle is useful to evaluate this complication.[48] It is important to distinguish the choroid plexus hemorrhage from the normal choroid plexus, which is also echogenic. The echogenicity anterior to the caudothalamic groove represents blood as the choroid plexus finishes at the caudothalamic groove, and the choroid plexus hemorrhage is diagnosed sonographically when the affected side is enlarged, or irregular in contour as compared with the contralateral nonaffected side.[51] [54] [55] [56] Sequelae, such as hydrocephalus and brain atrophy, can also be evaluated using ultrasound.[48] [57]
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Liver and Biliary System
Liver dysfunction in pediatric patients with congenital heart disease is associated with congestion and low cardiac output.[58] Liver complications after the Fontan procedure are known to be chronic in nature.[59] Acute liver failure after cardiovascular surgery is usually associated with low cardiac output during the operation.[60] [61] In addition, fatty liver or accumulation of debris within the biliary system may be caused by using medication or total parenteral nutrition.
#
Timing of Occurrence and Strategy for Diagnosis
Acute liver failure or liver sufficiency is usually accompanied with low cardiac output during operation and acute renal failure.[60] [61] Therefore, circulation status during the operation is important. The ultrasound should be the first method of diagnostic imaging used for inflammation of biliary system and differentiate from other liver diseases.[62] The contrast-enhanced CT or magnetic resonance imaging may be recommended to evaluate etiology of inflammation of biliary system, such as causative stone in the gallbladder or bile duct, if the etiology is not detected clearly buy ultrasound.[62]
-
Acute liver failure (liver sufficiency): patients with acute liver failure usually show evidence of low cardiac output and acute renal failure ([Fig. 13]).[60] [61] Acute liver failure after cardiovascular surgery may occasionally present with marked prolongation of the prothrombin time, which is associated with failure of hemostasis and hypoglycemia.[60] [61]
-
Fatty liver: fatty liver is a rare disease in pediatric patients ([Fig. 14]). However, it may appear in these patients as a result of medications or total parenteral nutrition.[63] [64] Liver disorder in the intensive care unit is occasionally caused by fatty liver.
-
Accumulation of debris within the biliary system: some drugs or total parenteral nutrition may result in the accumulation of debris within the biliary system ([Fig. 15]).[65] [66] In some cases, this complication required appropriate treatment.[66] Ultrasound is a useful modality to evaluate this condition.[65]
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Intestine
Gastrointestinal complications after cardiovascular surgery are associated with longer hospitalization periods.[67] These gastrointestinal complications include necrotizing enterocolitis, vocal cord paralysis, gastrointestinal bleeding, ileus, or enteritis.[1] [10] [67] [68] Necrotizing enterocolitis is reported to be the most common event.[67] [68] To prevent these complications, various enteral feeding programs are tested.[69] [70] [71]
Timing of Occurrence and Strategy for Diagnosis
Congenital heart disease is one of the risk factors for necrotizing enterocolitis. In addition, paradoxical hypertension may be occurred after repair of the coarctation of aorta.[72] The necrotizing enterocolitis occurs even before surgery or 1 day after surgery.[69] [70] [73] [74] The diagnosis of necrotizing enterocolitis is usually performed based on the radiograph according to Bell's staging criteria.[75] [76] [77] [78] The ultrasound provides the additional information to diagnose the necrotizing enterocolitis, therefore ultrasound is recommended as the next examination.[77] Paradoxical hypertension after repair of the coarctation of aorta was reported to be usually occurred 48 hours after operation. Clinical diagnosis could usually made based on the clinical sign.[72]
1. Necrotizing enterocolitis
Necrotizing enterocolitis more frequently occurs in pediatric patients with prematurity or those presenting with shock ([Figs. 16] and [17]).[68] Radiographic signs include a dilated intestine without peristalsis, intramural air, or portal venous gas.[69] Although radiography is a useful modality to evaluate these findings, ultrasound can more easily detect the portal venous gas and other findings such as the need for an urgent surgical intervention.[79] [80] [81]
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Sonographic Evaluation
It is important to evaluate the necessity of urgent surgical intervention in the presence of necrotizing enterocolitis. Presence or absence of intra-abdominal free air and echogenic ascites are important findings to recommend surgical intervention.[79] [80] [81] [82] [83] There are some reports that the cases with pneumatosis intestinalis confined to the colon had better prognosis than that extended to the small intestine, therefore evaluation for location of pneumatosis intestinalis could be useful.[79] [84] Portal venous gas, when detected, can be traced to its origin by following the hyperechoic foci in the portal vein along its branches with real-time ultrasound ([Fig. 16C] and [16D]; [Videos 3] [4] [5]; available in the online version).[81]
Video 3 Ultrasound image showing hyperechoic foci moving in the portal vein.
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Video 4 Hyperechoic foci seen moving from the splenic vein to portal vein.
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Video 5 Hyperechoic foci (arrows) seen in the inferior mesenteric vein, moving from the transverse and descending large colon. Free air and echogenic ascites are not detected and pneumatosis intestinalis is confined to the large colon. Therefore, this case was diagnosed as benign type of pneumatosis intestinalis and surgical intervention was not needed.
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2. Paradoxical hypertension results in postcoarctectomy syndrome or mesenteric arteritis
The coarctation of aorta is a little different from other congenital heart diseases. First, intra-abdominal of coarctation might be associated with occurrence of intestinal ischemia.[85] Second, paradoxical hypertension might be occurred after surgical repair of coarctation of the aorta.[72] [86] [87] The etiology is unclear but there appears to be a direct relationship to the hypertension that is observed in the postoperative period in these cases.[72] [86] [87] This complication might be result in abdominal pain, mesenteric arteritis, or arterial aneurysm.[72] [87] [88] [89] [90] Recognition of this complication and early treatment for this hypertension by using antihypertensive drugs will shorten the duration of symptoms.[72] [88] [89] Angiographic findings of this complication showed arterial segmental constriction, dilatation, or aneurysm.[87] [91] Ultrasound or CT was reported to be able to show the arterial lumen; therefore, these findings may be detected by ultrasound or CT.[92] [93]
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Kidney
Renal dysfunction, renal infectious disease, or drug-induced renal dysfunction may occur in pediatric patients after cardiovascular surgery.[1] Higher morbidity and mortality are associated with more severe acute kidney injuries, and this complication is also associated with a longer intensive care unit stay.[8] [94]
Timing of Occurrence and Strategy for Diagnosis
Onset of acute kidney injury is 1 to 27 days after operation.[94] In neonates, progression of acute kidney injury can occur within 48 hours after surgery[8]. However, acute kidney disease is diagnosed based on the clinical data such as serum creatine, not imaging modality, ultrasound might provide the information about presence or absence of urinary tract obstruction.[95] [96] [97] Doppler technique is useful to evaluate the resistivity index and it is important information about renal parenchymal damage and prediction of clinical outcomes.[97] [98] [99]
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Acute kidney injury: the sonographic findings for acute kidney injury are not specific but ultrasound may show enlargement or high echogenicity of the renal parenchyma ([Fig. 18]).[97] Doppler ultrasound may be useful to predict renal function.[8]
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Nephrocalcinosis: nephrocalcinosis may be caused by furosemide that is usually an important medication in intensive care units ([Fig. 19]). Foci with high echogenicity are easily detected by using ultrasound, and the presence or absence of hydronephrosis can be evaluated.[100]
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Urinary tract infection: urinary tract infection is one of the most frequent infectious foci in pediatric patients after cardiovascular surgery ([Figs. 20] and [21]).[1] [2] Ultrasound is reported to be useful in detecting the presence of hydronephrosis and to diagnose it as pyelonephritis or acute focal bacterial nephroma.[101]
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Vascular Complications Associated with Inserted Catheter and Drainage Tube Location
The risk of venous thrombotic events is higher in pediatric patients admitted to intensive care units.[102] The presence of a central venous catheter increases this risk.[102] Catheter-associated bloodstream infection is an important complication of care in children hospitalized with complex congenital heart disease.[103] In addition, phlebitis and osteomyelitis caused by thrombophlebitis have been reported.[104] Regardless of these potential complications, venous cannulation in intensive care units is usually unavoidable.
Timing of Occurrence and Strategy of Diagnosis
The timing of occurrence of thrombosis or phlebitis associated with catheter insertion is approximately 3 to 5 days after insertion.[105] [106] Physical examination is important to suspect thrombosis or phlebitis associated with catheter insertion.[107] In addition, ultrasound is a useful modality to evaluate these complications.[105] [106] If these complications are suspected to occur at intrathoracic vein or difficult location by using ultrasound, contrast-enhanced CT could be recommended.[108] Color Doppler is useful technique to detect the vessel and thrombosis.[105] [106] [109]
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Thrombosis (thrombophlebitis): venous thrombosis could be caused from an inserted catheter and patient conditions such as an underlying disease, or inadequate prophylaxis ([Figs. 22] and [23]).[102] [104] Pulmonary embolism or thrombophlebitis caused by venous thrombosis may be critical for pediatric patients.[110] [111] [112] Ultrasound is usually used to evaluate the presence of thrombosis and its complications.[109]
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Catheter migration: prevention of catheter migration is essential to avoid the complications associated with catheters ([Fig. 24]).[113] Ultrasound is a useful modality to guide cannulation and evaluate catheter migration.[113]
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Arrangement of the location of the drainage tube: ultrasound is useful to evaluate the location of the catheter or drainage tube ([Fig. 25]). The location may be changed based on the findings obtained in ultrasound evaluations.
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Endotracheal intubation: intubation-related issues are critical for pediatric patients in intensive care units. Repeated endotracheal intubation may be sometimes needed because of various underlying diseases ([Fig. 26]). Ultrasound has been reported to be useful for safe endotracheal intubation.[14] [114]
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Conclusion
Various complications may occur after cardiovascular surgery. Radiography and ultrasound are important modalities to evaluate and manage these complications.
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Conflict of Interest
None declared.
Ethical Approval
This research was performed in accordance with the tenets of the Declaration of Helsinki. This review article was approved by the ethics committee of our institution, and informed consent was waived.
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Address for correspondence
Publication History
Received: 03 June 2020
Accepted: 24 June 2020
Article published online:
09 September 2020
© 2020. Thieme. All rights reserved.
Georg Thieme Verlag KG
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