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Synlett 2021; 32(04): 391-394
DOI: 10.1055/s-0040-1707295
DOI: 10.1055/s-0040-1707295
cluster
Radicals – by Young Chinese Organic Chemists
Synthesis of Chiral Fluorides by Sequential Organocatalyzed Desymmetrization of Glutaric Anhydrides and Photoredox-Catalyzed Decarboxylic Fluorination
Financial support from National Natural Science Foundation of China (21732003) is acknowledged.


Abstract
We have developed an efficient method for the preparation of chiral fluorinated compounds by sequential organocatalyzed desymmetrization of 3-substituted glutaric anhydrides and photoredox-catalyzed decarboxylic fluorination. Chiral fluorides can be prepared in yields of up to 58% and with excellent enantioselectivities of up to 98% ee.
Key words
sequential catalysis - organocatalysis - photoredox catalysis - fluoro compounds - asymmetric catalysis - desymmetrizationSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1707295.
- Supporting Information
Publikationsverlauf
Eingereicht: 30. Juni 2020
Angenommen nach Revision: 26. August 2020
Artikel online veröffentlicht:
22. September 2020
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