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Synfacts 2020; 16(06): 0661
DOI: 10.1055/s-0040-1706971
DOI: 10.1055/s-0040-1706971
Metals in Synthesis
Nickel-Catalyzed Cross-Electrophile Coupling using Electrochemistry
Further Information
Publication History
Publication Date:
15 May 2020 (online)
![](https://www.thieme-connect.de/media/synfacts/202006/i_p053_s1_10-1055_s-0040-1706971.gif)
Significance
The authors describe a general nickel-catalyzed cross-electrophile coupling of functionalized alkenyl, aryl, and heteroaryl halides with various primary and secondary bromides using electrochemistry. The alkylated products were obtained in high yields.
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Comment
Key for high coupling yields was the use of the electron shuttle reagent Ni(η3-L)2, which efficiently prevents over-reduction and thus decomposition of the unsaturated halides. Significantly, this enables an easy scale up by performing the reaction at high currents on a 75 mmol scale.
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![](https://www.thieme-connect.de/media/synfacts/202006/i_p053_s1_10-1055_s-0040-1706971.gif)