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Synfacts 2021; 17(06): 0707
DOI: 10.1055/s-0040-1706212
DOI: 10.1055/s-0040-1706212
Peptide Chemistry
Manganese-Catalyzed Late-Stage Functionalization of Peptides
Kaplaneris N,
KaltenhÄuser F,
Sirvinskaite G,
Fan S,
De Oliveira T,
Conradi L.-C,
Ackermann L.
*
Georg-August-Universität Göttingen and German Center for Cardiovascular Research, Berlin, Germany
Late-Stage Stitching Enabled by Manganese-Catalyzed C–H Activation: Peptide Ligation and Access to Cyclopeptides.
Sci. Adv. 2021;
7
DOI: 10.1126/sciadv.abe6202.
Late-Stage Stitching Enabled by Manganese-Catalyzed C–H Activation: Peptide Ligation and Access to Cyclopeptides.
Sci. Adv. 2021;
7
DOI: 10.1126/sciadv.abe6202.
Key words
late-stage functionalization - manganese catalysis - macrocyclic peptides - C–H activation - hydroarylation
Significance
Structurally modified complex peptides play an important role in the field of peptide-drug discovery. In this context, a Mn-catalyzed C–H bond-activation strategy has been developed for the synthesis of complex peptides and cyclic peptides.
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Comment
The Mn(I)-catalyzed C–H hydroarylation of peptides proceeded smoothly to afford structurally complex peptides and macrocyclic peptides in high yields. The reaction shows high chemo- and regioselectivities.
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Publication History
Article published online:
18 May 2021
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