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J Pediatr Intensive Care 2020; 09(03): 213-215
DOI: 10.1055/s-0039-1700963
Case Report
Georg Thieme Verlag KG Stuttgart · New York

Severe Hyponatraemia Associated with the Use of Arginine–Vasopressin in Two Neonates with Complex Congenital Heart Disease

Nicolas Leister
1   Department of Anaesthesiology and Intensive Care Medicine, University Hospital of Cologne, Cologne, Germany
,
Daniel Rohe
1   Department of Anaesthesiology and Intensive Care Medicine, University Hospital of Cologne, Cologne, Germany
,
Christine Schumacher
1   Department of Anaesthesiology and Intensive Care Medicine, University Hospital of Cologne, Cologne, Germany
,
Uwe Trieschmann
1   Department of Anaesthesiology and Intensive Care Medicine, University Hospital of Cologne, Cologne, Germany
,
Christoph Menzel
1   Department of Anaesthesiology and Intensive Care Medicine, University Hospital of Cologne, Cologne, Germany
,
Tobias Hannes 
2   Department of Paediatric Cardiology, University of Cologne, Cologne, Germany
3   Department of Paediatric Critical Care Medicine and Neonatology, University Children's Hospital, Cologne, Germany
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Publikationsverlauf

08. September 2019

01. Dezember 2019

Publikationsdatum:
13. Januar 2020 (online)

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Abstract

We report two cases of neonates with complex congenital heart disease and volume, catecholamine, and corticosteroid refractory shock treated with arginine–vasopressin. Arginine–vasopressin was able to reverse critical hypotension, but both patients developed severe hyponatremia, which recovered after discontinuation of arginine–vasopressin. Close control and prompt substitution of serum sodium is required in neonates with advanced heart failure on high-dose vasopressin therapy.

Keywords

arginine–vasopressin - refractory shock - hypotension - hyponatremia - congenital heart disease
 

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