J Pediatr Intensive Care 2019; 08(04): 226-232
DOI: 10.1055/s-0039-1692669
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Prescribing Patterns of Continuous Infusions in Nonobese versus Obese Children Admitted to the Pediatric Intensive Care Unit

1   Department of Pharmacy: Clinical and Administrative Sciences, University of Oklahoma College of Pharmacy, Oklahoma City, Oklahoma, United States
,
Katy Stephens
2   Department of Clinical Pharmacy, University of Tennessee College of Pharmacy, Nashville, Tennessee, United States
,
Philip Barker
2   Department of Clinical Pharmacy, University of Tennessee College of Pharmacy, Nashville, Tennessee, United States
,
Erica Bergeron
2   Department of Clinical Pharmacy, University of Tennessee College of Pharmacy, Nashville, Tennessee, United States
,
Sin Yin Lim
1   Department of Pharmacy: Clinical and Administrative Sciences, University of Oklahoma College of Pharmacy, Oklahoma City, Oklahoma, United States
,
2   Department of Clinical Pharmacy, University of Tennessee College of Pharmacy, Nashville, Tennessee, United States
,
Teresa V. Lewis
1   Department of Pharmacy: Clinical and Administrative Sciences, University of Oklahoma College of Pharmacy, Oklahoma City, Oklahoma, United States
,
Stephen Neely
2   Department of Clinical Pharmacy, University of Tennessee College of Pharmacy, Nashville, Tennessee, United States
,
Jamie L. Miller
1   Department of Pharmacy: Clinical and Administrative Sciences, University of Oklahoma College of Pharmacy, Oklahoma City, Oklahoma, United States
› Author Affiliations
Further Information

Publication History

29 April 2019

15 May 2019

Publication Date:
21 June 2019 (online)

Abstract

This retrospective study compared the continuous infusions prescribed for obese and nonobese children. Ninety-five (13.2%) received an infusion. A greater percentage of obese (n = 42/168) versus nonobese (53/552) children received infusions, p < 0.01. No difference was noted in the median number of infusions between the obese and nonobese groups, 2 versus 2, p = 0.975. The top 20 prescribed infusions included ten (50%) for sedation/analgesia or neuromuscular blockade and six (30%) for hemodynamic support. A literature search was performed for these 20 agents to determine pharmacokinetics, pharmacodynamics, and dosing in obese children and revealed six studies evaluating fentanyl (n = 2), midazolam (n = 1), and propofol (n = 3).

 
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