Stereoselective Macrocyclization of Peptides in CyClick Chemistry
CyClick Chemistry for the Synthesis of Cyclic Peptides.
Angew. Chem. Int. Ed. 2019;
21 January 2020 (online)
The pharmaceutical industry’s interest in peptide therapeutics is increasing owing to their low toxicities, high specificities towards targeted proteins, and so on. The authors describe a stereoselective macrocyclization of peptides through click chemistry.
This DMAP-mediated intermolecular cyclization gives the desired cyclic peptides in moderate to high yields without the formation of linear oligopeptides through intramolecular reactions.