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Synfacts 2019; 15(11): 1257
DOI: 10.1055/s-0039-1691025
DOI: 10.1055/s-0039-1691025
Metals in Synthesis
Palladium-Catalyzed Synthesis of Carboxylic Acids
Sang R,
Kucmierczyk P,
Dühren R,
Razzaq R,
Dong K,
Liu J,
Franke R.
*
Jackstell R,
Beller M.
* Evonik Performance Materials gmbh, marl, Ruhr-Universität, Bochum, and Universität Rostock, Germany
Synthesis of Carboxylic Acids by Palladium-Catalyzed Hydroxycarbonylation.
Angew. Chem. Int. Ed. 2019;
58: 14365-14373
Synthesis of Carboxylic Acids by Palladium-Catalyzed Hydroxycarbonylation.
Angew. Chem. Int. Ed. 2019;
58: 14365-14373
Further Information
Publication History
Publication Date:
18 October 2019 (online)
Significance
The authors report a very general and high yielding palladium-catalyzed synthesis of carboxylic acids, starting from alkenes. The method is performed in aqueous environment and uses only 0.25 mol% of Pd(acac)2. High pressured carbon monoxide is used as ′CO′ source, ensuring a good atom economy.
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Comment
Various substituted alkenes (over 40 examples) have been successfully transformed into their corresponding carboxylic acids. The method provides the product in high n/iso ratio and can tolerate highly reactive functional groups, such as ketones or phosphates.
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