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Synfacts 2019; 15(10): 1143
DOI: 10.1055/s-0039-1690669
DOI: 10.1055/s-0039-1690669
Metals in Synthesis
The Kulinkovich Reaction
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
17. September 2019 (online)
![](https://www.thieme-connect.de/media/synfacts/201910/i_p118_s1_10-1055_s-0039-1690669.gif)
Significance
In 1991, Kulinkovich and co-workers reported the titanium-catalyzed reaction of simple esters with ethylmagnesium bromide, leading to substituted cyclopropanols in excellent yields.
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Comment
Interestingly, in the presence of the titanium catalyst, ethylmagnesium bromide is transformed into an ethylene dianion, which is reactive towards alkylcarboxylic esters.
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![](https://www.thieme-connect.de/media/synfacts/201910/i_p118_s1_10-1055_s-0039-1690669.gif)