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Synfacts 2019; 15(10): 1143
DOI: 10.1055/s-0039-1690669
Metals in Synthesis
© Georg Thieme Verlag Stuttgart · New York

The Kulinkovich Reaction

Contributor(s):
Paul Knochel
,
Moritz Balkenhohl
Kulinkovich OG. * Sviridov SV, Vasilevski DA. Belarusian State University, Minsk, Belarus
Titanium(IV) Isopropoxide-Catalyzed Formation of 1-Substituted Cyclopropanols in the Reaction of Ethylmagnesium Bromide with Methyl Alkanecarboxylates.

Synthesis 1991; 234-234
Article in Thieme ConnectGoogle Scholar
Further Information

Publication History

Publication Date:
17 September 2019 (online)

 
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Key words

cyclopropanes - Grignard reagent - titanium

Significance

In 1991, Kulinkovich and co-workers reported the titanium-catalyzed reaction of simple esters with ethylmagnesium bromide, leading to substituted cyclopropanols in excellent yields.


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Comment

Interestingly, in the presence of the titanium catalyst, ethylmagnesium bromide is transformed into an ethylene dianion, which is reactive towards alkylcarboxylic esters.


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