Synfacts 2019; 15(08): 0950
DOI: 10.1055/s-0039-1690479
Peptide Chemistry
© Georg Thieme Verlag Stuttgart · New York

Azotide Ligands for Hetero-Diels–Alder Reactions

Rezensent(en):
Hisashi Yamamoto
,
Tomohiro Hattori
Jacobsen CB, Nielsen DS, Meldal M. * Diness F. * University of Copenhagen, Denmark
Azotides as Modular Peptide-Based Ligands for Asymmetric Lewis Acid Catalysis.

J. Org. Chem. 2019;
84: 6940-6945
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
18. Juli 2019 (online)

 

Significance

Azotides, which are abundantly found as scaffolds in natural products, are known to coordinate metal ions. The author report new azotide ligands for enantioselective Lewis acid catalysis.


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Comment

The ligands were readily prepared from the chiral pool of amino acids and demonstrated enantioselectivity when used as ligands in a cobalt(II)-catalyzed hetero-Diels–Alder reaction.


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