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Synfacts 2019; 15(11): 1259
DOI: 10.1055/s-0039-1690320
DOI: 10.1055/s-0039-1690320
Metals in Synthesis
Asymmetric C–H Alkylation of Fluoroarenes with Alkenes via Nickel/NHC Catalysis
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
18. Oktober 2019 (online)
![](https://www.thieme-connect.de/media/synfacts/201911/i_l128_s1_10-1055_s-0039-1690320.gif)
Significance
The authors demonstrate an unprecedented catalytic enantioselective C–H alkylation of polyfluoroarenes. The annulation displayed complete endo selectivity, with exclusive C–H over C–F activation, and excellent enantioselectivity.
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Comment
In addition to conferring excellent enantioselectivity, the use of the rather bulky chiral N-heterocyclic carbene ligand for the nickel catalyst prevented any competition from C–F activation; as such, there was complete chemo- and regioselectivity.
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![](https://www.thieme-connect.de/media/synfacts/201911/i_l128_s1_10-1055_s-0039-1690320.gif)