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Synfacts 2020; 16(04): 0487
DOI: 10.1055/s-0039-1690060
Peptide Chemistry
© Georg Thieme Verlag Stuttgart · New York

Solid-State Synthesis of a β-Turn Mimetic

Contributor(s):
Hisashi Yamamoto
,
Tomohiro Hattori
Golebiowski A. * Klopfenstein SR, Shao X, Chen JJ, Colson A.-O, Grieb AL, Russell AF. Procter & Gamble Pharmaceuticals, Mason, USA
Solid-Supported Synthesis of a Peptide β-Turn Mimetic.

Org. Lett. 2000;
2: 2615-2617
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Publication History

Publication Date:
18 March 2020 (online)

 
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Key words

solid-state synthesis - β-turn - peptide mimetics - Ugi reaction

Significance

The β-turn is one of the most interesting structural peptides and has attracted significant attention not only from biologists, but also from organic chemists. In 2000, the authors have demonstrated the construction of a β-turn mimetic by solid-supported synthesis.


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Comment

Solid-supported synthesis is an effective method for forming peptide bonds. The Ugi reaction was used in the cyclization step to afford the β-turn mimetic in high yield.


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