J Pediatr Infect Dis 2019; 14(04): 171-175
DOI: 10.1055/s-0039-1685162
Original Article
Georg Thieme Verlag KG Stuttgart · New York

The Seroprevalence of Hand-Foot-Mouth Disease in Preschool Children

Esma Merve Cinar
1   Department of Pediatrics, Sakarya University Faculty of Medicine, Sakarya, Turkey
,
Mustafa Kosecik
2   Department of Pediatrics, Bursa Uludağ University Faculty of Medicine, Bursa, Turkey
,
Ferhat Gurkan Aslan
3   Fatih Sultan Mehmet Research and Training Hospital, Microbiology Laboratory, İstanbul, Turkey
,
Mustafa Buyukavcı
1   Department of Pediatrics, Sakarya University Faculty of Medicine, Sakarya, Turkey
,
Mehmet Koroglu
4   Department of Microbiology, Sakarya University Faculty of Medicine, Sakarya, Turkey
,
Bahri Elmas
1   Department of Pediatrics, Sakarya University Faculty of Medicine, Sakarya, Turkey
,
Mustafa Altındis
4   Department of Microbiology, Sakarya University Faculty of Medicine, Sakarya, Turkey
› Author Affiliations
Funding This study was supported by Sakarya University Scientific Research Projects Coordinator (Project number: 2017-40-02-008).
Further Information

Publication History

01 November 2018

01 March 2019

Publication Date:
03 April 2019 (online)

Abstract

Hand-foot-mouth disease (HFMD) is a systemic and mostly uncomplicated infectious disease caused by the virus of the enterovirus family and manifests as skin and mucosal lesions. Enterovirus 71 (EV71) and coxsackievirus A16 (CA16) are the most commonly detected infectious agents. It is generally observed in children under 5 years of age. In this study, our objective was to determine the seroprevalence of HFMD in preschool children in Sakarya region. A total of 380 children between 1 and 6 years of age were included in the study. Sociodemographic information, clinical findings, and possible risk factors were recorded on a data collection form. Later, serum anti-EV71 and anti-CA16 IgG (immunoglobulin G) antibodies were measured by ELISA. Amongst the 380 children, EV71 IgG positivity was 57.9% and CA16 IgG antibody positivity was 57.4%. There was no difference in seroprevalence between the genders (p > 0.05). Anti-EV71 and anti-CA16 IgG antibody positivity was significantly higher in children aged 1, 2, 3, and 4 years than in 5-year olds (p < 0.05). Seroprevalence was significantly lower in children of mothers who washed their hands before feeding (p < 0.01). High HFMD seroprevalence (> 50%) was observed in the preschool period in the Sakarya region, especially in children aged 1 to 4 years. To prevent infections for which there is no specific treatment, it is very important that the hygiene rules are complied with; in particular, children and their caregivers should pay attention to hand cleansing. We believe that more seroprevalence studies should be performed from different regions to show the status of the disease in our country.

 
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