Journal of Pediatric Neurology 2020; 18(03): 144-147
DOI: 10.1055/s-0039-1683999
Case Report
Georg Thieme Verlag KG Stuttgart · New York

Posterior Reversible Encephalopathy Syndrome in an Adolescent with Acute Poststreptococcal Glomerulonephritis

Çağla Serpil Doğan
1   Division of Pediatric Nephrology, Department of Pediatrics, Antalya Training and Research Hospital, Antalya, Turkey
,
Gülşah Kaya Aksoy
1   Division of Pediatric Nephrology, Department of Pediatrics, Antalya Training and Research Hospital, Antalya, Turkey
,
Muhammed Gültekin Kutluk
2   Division of Pediatric Neurology, Department of Pediatrics, Antalya Training and Research Hospital, Antalya, Turkey
,
Mehmet Burak Özkan
3   Division of Pediatric Radiology, Department of Radiology, Antalya Training and Research Hospital, Antalya, Turkey
› Author Affiliations
Further Information

Publication History

20 November 2018

27 February 2019

Publication Date:
27 March 2019 (online)

Abstract

Posterior reversible encephalopathy syndrome (PRES) is a rare but severe complication of acute poststreptococcal glomerulonephritis (APSGN) in children. A 13-year old boy was diagnosed with APSGN based on clinical, laboratory, and renal biopsy findings. On the third hospital day, his blood pressure (BP) was 130/80 mm Hg on antihypertensive and diuretic treatment. He then developed confusion, blurry vision, and changes in speech and behavior. Over the next few hours, his BP increased to 160/90 to 170/90 mm Hg (99th percentile, 135/90 mm Hg). Magnetic resonance imaging of the brain revealed prominent hyperintensities in the right temporal, right temporo-occipital, and right parieto-occipital gray, and white matter on T2-weighted and fluid-attenuated inversion recovery images, compatible with PRES (posterior reversible encephalopathy syndrome). Electroencephalography showed generalized epileptiform activity. After treatment with anticonvulsant and additional antihypertensive medications, his clinical symptoms and neuroimaging findings were resolved. Posterior reversible encephalopathy syndrome should be considered in the differential diagnosis of patients with APSGN developing sudden neurological symptoms without severe increases in BP.

 
  • References

  • 1 Onder AM, Lopez R, Teomete U. , et al. Posterior reversible encephalopathy syndrome in the pediatric renal population. Pediatr Nephrol 2007; 22 (11) 1921-1929
  • 2 Ishikura K, Hamasaki Y, Sakai T, Hataya H, Mak RH, Honda M. Posterior reversible encephalopathy syndrome in children with kidney diseases. Pediatr Nephrol 2012; 27 (03) 375-384
  • 3 Adikari M, Priyangika D, Marasingha I, Thamotheram S, Premawansa G. Post-streptococcal glomerulonephritis leading to posterior reversible encephalopathy syndrome: a case report. BMC Res Notes 2014; 7: 644
  • 4 Endo A, Fuchigami T, Hasegawa M. , et al. Posterior reversible encephalopathy syndrome in childhood: report of four cases and review of the literature. Pediatr Emerg Care 2012; 28 (02) 153-157
  • 5 National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 2004; 114 (2, Suppl 4th Report): 555-576
  • 6 Rodriguez-Iturbe B, Musser JM. The current state of poststreptococcal glomerulonephritis. J Am Soc Nephrol 2008; 19 (10) 1855-1864
  • 7 Zaki SA, Shanbag P. Unusual presentation of poststreptococcal glomerulonephritis as posterior reversible encephalopathy syndrome. J Pediatr Neurosci 2014; 9 (01) 42-44
  • 8 Adikari M, Priyangika D, Marasingha I, Thamotheram S, Premawansa G. Post-streptococcal glomerulonephritis leading to posterior reversible encephalopathy syndrome: a case report. BMC Res Notes 2014; 7: 644
  • 9 Ishikura K, Ikeda M, Hamasaki Y. , et al. Posterior reversible encephalopathy syndrome in children: its high prevalence and more extensive imaging findings. Am J Kidney Dis 2006; 48 (02) 231-238
  • 10 Ninomiya I, Kanazawa M, Akaiwa Y. , et al. Apparent diffusion coefficient reduction might be a predictor of poor outcome in patients with posterior reversible encephalopathy syndrome. J Neurol Sci 2017; 381: 1-3
  • 11 Kasap B, Çarman KB, Yiş U. A case of acute post-streptococcal glomerulonephritis that developed posterior reversible encephalopathy syndrome. Turk Pediatri Ars 2014; 49 (04) 348-352
  • 12 Kamiya-Matsuoka C, Tummala S. Electrographic patterns in patients with posterior reversible encephalopathy syndrome and seizures. J Neurol Sci 2017; 375: 294-298