Synthesis of Cyclic and Bicyclic Peptides
Chemoselective Peptide Cyclization and Bicyclization Directly on Unprotected Peptides.
J. Am. Chem. Soc. 2019;
18 October 2019 (online)
Due to their unique properties, cyclic peptides and their synthesis have received considerable attention from medicinal chemists. The authors have developed an ortho-phthalaldehyde-guided chemoselective cyclization of unprotected peptides.
This cyclization reaction for the synthesis of cyclic and bicyclic peptides is guided successfully by ortho-phthalaldehyde. The target compounds are obtained in high conversion yields with excellent chemoselectivity.