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J Knee Surg 2018; 31(10): 946-951
DOI: 10.1055/s-0038-1672122
Special Focus Section
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Albumin, Prealbumin, and Transferrin May Be Predictive of Wound Complications following Total Knee Arthroplasty

Martin Roche
1   Department of Orthopedic Surgery, Holy Cross Orthopedic Institute, Fort Lauderdale, Florida
,
Tsun Yee Law
1   Department of Orthopedic Surgery, Holy Cross Orthopedic Institute, Fort Lauderdale, Florida
,
Jennifer Kurowicki
1   Department of Orthopedic Surgery, Holy Cross Orthopedic Institute, Fort Lauderdale, Florida
2   Department of Orthopaedic Surgery, St. Joesph's Regional Medical Center, Paterson, New Jersey
,
Nipun Sodhi
3   Department of Orthopaedic Surgery, Lenox Hill Hospital, New york, New York
,
Samuel Rosas
1   Department of Orthopedic Surgery, Holy Cross Orthopedic Institute, Fort Lauderdale, Florida
4   Department of Orthopedic Surgery, Wake Forest School of Medicine, Winston-Salem, North Carolina
,
Leah Elson
5   School of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, Florida
,
Spencer Summers
6   Department of Orthopaedic Surgery and Rehabilitation, University of Miami Health System, Miami, Florida
,
Karim Sabeh
7   Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical school, Boston MA
,
Michael A. Mont
3   Department of Orthopaedic Surgery, Lenox Hill Hospital, New york, New York
› Author Affiliations
Further Information

Publication History

02 April 2018

15 August 2018

Publication Date:
03 October 2018 (online)

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Abstract

Nutritional status has become increasingly important in optimizing surgical outcomes and preventing postoperative infection and wound complications. However, currently, there is a paucity in the orthopaedics literature investigating the relationship between nutritional status and wound complications following total knee arthroplasty (TKA). Therefore, the purpose of this study was to determine the prevalence of (1) postoperative infections, (2) wound complications, (3) concomitant infection with wound (CoIW) complication, and (4) infection followed by wound complication by using (1) albumin, (2) prealbumin, and (3) transferrin levels as indicators of nutritional status. These four different outcome measures were chosen as they are encountered commonly in daily clinical practice. A retrospective review of a national private payer database for patients who underwent TKA with postoperative infections and wound complications stratified by preoperative serum albumin (normal: 3.5–5 g/dL), prealbumin (normal: 16–35 mg/dL), and transferrin levels (normal: 200–360 mg/dL) between 2007 and 2015 was conducted. Patients were identified by Current Procedural Terminology (CPT), International Classification of Disease, ninth revision (ICD-9) codes, and Logical Observation Identifiers Names and Codes (LOINC). Linear regression was performed to evaluate changes over times. Yearly rates of infection, as well as a correlation and odds ratio analysis of nutritional laboratory values to postoperative complications, were also performed. Our query returned a total of 161,625 TKAs, of which 11,047 (7%) had postoperative wound complications, 18,403 (11%) had infections, 6,296 (34%) had CoIW, and 4,877 (4%) patients with infection developed wound complications. Albumin was the most commonly ordered laboratory test when assessing complications (96%). Wound complications, infections, CoIW, and infection with wound complications after were higher in those below the normal range: albumin <3.5 g/dL (9, 14, 6, and 5%), prealbumin <15 mg/dL (20, 23, 13, and 12%), and transferrin <200 mg/dL (12, 17, 6, and 6%). Preoperative albumin, prealbumin, and transferrin values falling below the normal range represented an increased risk for postoperative complications. Those patients who were in the normal range, however, did not have an increased risk. Therefore, our results suggest that preoperative nutritional optimization can play an important role in reducing the risk for postoperative complications.

Keywords

total knee arthroplasty - joint replacement - wound complications - albumin - prealbumin - transferrin - malnutrition - infection
 

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