New Diagnostic Possibilities for Neonatal Sepsis

Abstract

Progress in neonatal care has decrease morbidity and mortality due to neonatal sepsis (NS). Although diagnosis of sepsis continues to rely on blood culture, this method is too slow and limited by false-negative results. There are numerous sepsis biomarkers that have been evaluated for the early diagnosis of NS, but, to date, there is no single ideal biomarker, though novel biomarkers are becoming more sophisticated and specific in their clinical applications. This review provides an overview of the current diagnostic approaches available or under development for diagnosing NS.

Keywords

neonate - sepsis - biomarkers - diagnosis

• References

• 1 Mithal LB, Palac HL, Yogev R, Ernst LM, Mestan KK. Cord blood acute phase reactants predict early onset neonatal sepsis in preterm infants. PLoS One 2017; 12 (01) e0168677
• 2 Ye Q, Du LZ, Shao WX, Shang SQ. Utility of cytokines to predict neonatal sepsis. Pediatr Res 2017; 81 (04) 616-621
• 3 Zhou M, Cheng S, Yu J, Lu Q. Interleukin-8 for diagnosis of neonatal sepsis: a meta-analysis. PLoS One 2015; 10 (05) e0127170
• 4 Shi J, Tang J, Chen D. Meta-analysis of diagnostic accuracy of neutrophil CD64 for neonatal sepsis. Ital J Pediatr 2016; 42 (01) 57-65
• 5 Yang AP, Liu J, Yue LH, Wang HQ, Yang WJ, Yang GH. Neutrophil CD64 combined with PCT, CRP and WBC improves the sensitivity for the early diagnosis of neonatal sepsis. Clin Chem Lab Med 2016; 54 (02) 345-351
• 6 Poggi C, Bianconi T, Gozzini E, Generoso M, Dani C. Presepsin for the detection of late-onset sepsis in preterm newborns. Pediatrics 2015; 135 (01) 68-75
• 7 Montaldo P, Rosso R, Santantonio A, Chello G, Giliberti P. Presepsin for the detection of early-onset sepsis in preterm newborns. Pediatr Res 2017; 81 (02) 329-334
• 8 Pugni L, Pietrasanta C, Milani S. , et al. Presepsin (soluble CD14 subtype): reference ranges of a new sepsis marker in term and preterm neonates. PLoS One 2015; 10 (12) e0146020
• 9 Pammi M, Flores A, Versalovic J, Leeflang MM. Molecular assays for the diagnosis of sepsis in neonates. Cochrane Database Syst Rev 2017; 2: CD011926
• 10 Fanos V, Caboni P, Corsello G. , et al. Urinary (1)H-NMR and GC-MS metabolomics predicts early and late onset neonatal sepsis. Early Hum Dev 2014; 90 (01) (Suppl. 01) S78-S83
• 11 Sarafidis K, Chatziioannou AC, Thomaidou A. , et al. Urine metabolomics in neonates with late-onset sepsis in a case-control study. Sci Rep 2017; 7: 45506
• 12 Fairchild KD, Schelonka RL, Kaufman DA. , et al. Septicemia mortality reduction in neonates in a heart rate characteristics monitoring trial. Pediatr Res 2013; 74 (05) 570-575
• 13 Coggins SA, Weitkamp JH, Grunwald L. , et al. Heart rate characteristic index monitoring for bloodstream infection in an NICU: a 3-year experience. Arch Dis Child Fetal Neonatal Ed 2016; 101 (04) F329-F332
• 14 Leante-Castellanos JL, Martínez-Gimeno A, Cidrás-Pidré M, Martínez-Munar G, García-González A, Fuentes-Gutiérrez C. Central-peripheral temperature monitoring as a marker for diagnosing late-onset neonatal sepsis. Pediatr Infect Dis J 2017; 36 (12) e293-e297
• 15 Kuzniewicz MW, Puopolo KM, Fischer A. , et al. A quantitative, risk-based approach to the management of neonatal early-onset sepsis. JAMA Pediatr 2017; 171 (04) 365-371