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Nuklearmedizin 1993; 32(01): 52-56
DOI: 10.1055/s-0038-1629644
Review Article – Übersichtsartikel
Schattauer GmbH

Role of Paramagnetic Ions and Water Proton Spin-Lattice Relaxation Time in Biological Systems

S. F. Akber
1   From the Department of Radiation Therapy and Radiology. York Hospital. York. PA, USA
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Publication History

Received: 04 June 1992

Publication Date:
02 February 2018 (online)

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Summary

This paper summarizes the observations of different studies concerning the influence of paramagnetic ions on spin-lattice relaxation times in magnetic resonance imaging. Based on findings that manganese ion content in cancer tissues is decreased in comparison to normal tissues, the results of different papers analysing the influence of tissue manganese concentration on spin- lattice relaxation times are collected and compared. Neither the comparison between different organs, different animals nor the comparison between different tissues (normal and malignant) showed correlations of practical consequences between manganese concentrations and spin-lattice relaxation times. These results are consistent with those from studies with copper and iron ions in living systems.

Zusammenfassung

Die vorliegende Arbeit faßt als Literaturübersicht Beobachtungen über die Beeinflussung der T1-Relaxationszeit bei der Kernspintomographie durch paramagnetische Ionen zusammen. Ausgehend von Beobachtungen einer niedrigeren Mangankonzentration in karzinomatösen Geweben, verglichen mit normalen Geweben, werden die Ergebnisse verschiedener Studien zur Beeinflussung der T1-Relaxationszeiten durch Organ- und Tumor-Mangankonzentrationen zusammengestellt und verglichen. Weder im Vergleich verschiedener Organe, verschiedener Tierarten noch im Vergleich verschiedener Gewebe (normales und tumoröses Gewebe) fanden sich verwertbare Korrelationen zwischen Mangankonzentrationen und T1-Relaxationszeiten. Damit sind die Ergebnisse denen bei Kupfer- und Eisenionen in lebenden Geweben vergleichbar.

Key words

Paramagnetic ions - manganese - spin-lattice relaxation time - magnetic resonance imaging

Schlüsselwörter

Paramagnetische Ionen - Mangan - T1-Relaxation - Kernspintomographie
 

  • REFERENCES

  • 1 Block RE, Maxwell GP, Branam DL. Nuclear spin relaxation in solutions prepared from normal and tumor hepatic tissues. J Natl Cancer Inst 1977; 59: 1731-5.
    CrossrefPubMedGoogle Scholar
  • 2 Cameron IL, Virginia A, Fullerton GD. Characterization of proton NMR relaxation times in normal and pathological tissues by correlation with other tissue parameters. Magn Reson Imaging 1984; 02: 97-106.
    CrossrefPubMedGoogle Scholar
  • 3 Clifford J. et al. In: Membrane Models and the formation of biological membranes. Bolis L, Pethica BA. (eds). Amsterdam: Proc Inti Conf Biol Memb. NATO Advanced Study Institute, North Holland Publishing Co; 1968: 19.
  • 4 Cope FW. Nuclear magnetic resonance evidence using D2O for structured water in muscle and brain. Biophys J 1969; 09: 303.
    CrossrefPubMedGoogle Scholar
  • 5 Cottom GL, Vasek A, Lusted D. Water proton relaxation rates in various tissues. Res Commun Chem Pathol Pharmacol 1972; 04: 495-502.
    Google Scholar
  • 6 Damadian R, Zaner K, Hor D. Human tumors detected by nuclear magnetic resonance. Proc Natl Acad Sei USA 1974; 71: 1471-3.
    CrossrefPubMedGoogle Scholar
  • 7 Fahlvik AE, Holtz E, Klaveness JO. Relaxation efficacy of paramagnetic and super paramagnetic microspheres in liver and spleen. Magn Reson Imaging 1990; 08: 363-9.
    CrossrefPubMedGoogle Scholar
  • 8 Fore H, Morton RA. Manganese in rabbit tissues. Biochem J 1952; 51: 600-3.
    CrossrefPubMedGoogle Scholar
  • 9 Hurley LS, Keen CL. Manganese in animal tissues and fluids. In: Trace Elements in Human and Animal Nutrition. Underwood EJ. (ed). New York: Academic Press; 1984: 186-203.
    Google Scholar
  • 10 Ling GN, Tucker M. NMR relaxation and water contents in normal tissues and cancer cells. In: NMR in Medicine. Damadian R. (ed). Berlin: Springer; 1981: 161-74.
    Google Scholar
  • 11 Ling CN, Foster MA. Phys Med Biol. 1982; 27: 853.
    PubMedGoogle Scholar
  • 12 Ling GN. Further studies on the role of paramagnetic ion contents on the NMR relaxation time. T1 of normal tissues and cancer cells. Physiol Chem Phys Med NMR 1989; 21: 15-8.
    PubMedGoogle Scholar
  • 13 Ling GN, Kolebic T, Damadian R. Low paramagnetic ion content in cancer cells: Its significance in cancer detection by magnetic resonance imaging. Physiol Chem Phys Med 1990; 22: 1-14.
    Google Scholar
  • 14 Negendank W, Corbett T, Crowley M, Kellog C. Evidence for a contribution of paramagnetic ions to water proton spin-lattice relaxation time in normal and malignant mouse tissues. Mag Reson Med 1991; 18: 280-93.
    CrossrefPubMedGoogle Scholar
  • 15 Schumacher JH, Matys ER, Clorius JH. q et al. Contribution of paramagnetic trace elements to the spin-lattice relaxation time in the liver. Invest Radiol 1985; 20: 601-8.
    CrossrefPubMedGoogle Scholar
  • 16 Shah SS, Ranade SS, Kasturi SR. q et al. Significance of water proton spin-lattice relaxation times in normal and malignant tissues and their subcellular fractions. Mag Reson Imag 1982; 01: 91.
    CrossrefPubMedGoogle Scholar
  • 17 Shah SS, Ranade SS, Kasturi SR, Phadke RS, Advani SH. Distinction between normal and leukemic bone marrow by water protons nuclear magnetic resonance relaxation times. Mag Reson Imag 1982; 01: 23-8.
    CrossrefPubMedGoogle Scholar
  • 18 Tipton IH, Cook MJ. Health Phys. 1965; 09: 103.
    Google Scholar