Thromb Haemost 2001; 86(01): 413-419
DOI: 10.1055/s-0037-1616239
Research Article
Schattauer GmbH

Annexins: Key Regulators of Haemostasis, Thrombosis, and Apoptosis

Chris P. M. Reutelingsperger
1   Department of Biochemistry, Cardiovascular Research Institute, Maastricht, The Netherlands
› Author Affiliations
Further Information

Publication History

Publication Date:
12 December 2017 (online)

Summary

Annexins form a family of proteins on the basis of structural and functional criteria. Their physiological relevance is still not fully understood, but is thought to involve phospholipid membrane associated processes. Recent data shed clues about their function in the regulation of thrombosis, haemostasis and apoptosis. These data arise from a multitude of physicochemical, cell biological, animal and clinical studies. This review presents this data and discusses them in the light of the novel understanding that apoptotic cells can contribute to thrombotic and haemostatic processes.

 
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