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Thromb Haemost 2001; 86(01): 276-288
DOI: 10.1055/s-0037-1616225
Research Article
Schattauer GmbH

The Role of ITAM- and ITIM-coupled Receptors in Platelet Activation by Collagen

Steve P. Watson
1   Departments of Pharmacology, John Radcliffe Hospital, Oxford, UK
,
Naoki Asazuma   2
,
Ben Atkinson
,
Oscar Berlanga
,
Denise Best
,
Regis Bobe
,
Gavin Jarvis
,
Stuart Marshall
,
Daniel Snell
,
Margaret Stafford
4   Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
,
David Tulasne
,
Jonathan Wilde
,
Peter Wonerow
,
Jon Frampton
4   Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
› Author Affiliations
Further Information

Publication History

Publication Date:
12 December 2017 (online)

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Summary

The major activation-inducing collagen receptor glycoprotein VI (GPVI) has been cloned within the last two years. It is a member of the Ig superfamily of proteins and is constitutively associated with the ITAM-bearing Fc receptor γ-chain (FcR γ-chain). GPVI signals through a pathway that involves several of the proteins used by Fc, B- and T-lymphocyte receptors and which takes place in glycolipid-enriched membrane domains in the plasma membrane known as GEMs. Responses to GPVI are regulated by PECAM-1 (CD31) and possibly other ITIM-bearing receptors. Despite a pivotal role for GPVI, there are important differences between signalling events to collagen and GPVI-specific ligands. This may reflect a role for co-receptors in the response to collagen.

Key words

Collagen - GPVI - signal transduction - tyrosine phosphorylation - ITAM - ITIM

2 Present address: Department of Clinical and Laboratory Medicine, Yamanashi Medical College, Shimokato 1110, Tamaho, Nakakoma, Yamanashi 409-38, Japan


 

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