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Thromb Haemost 2005; 93(01): 175-177
DOI: 10.1055/s-0037-1616161
Case Report
Schattauer GmbH

Neuropharmacological therapy of polycythemia vera: roles of circulating catecholamines and serotonin

Fuad Lechin
1   Department of Physiological Sciences, Sections of Neurochemical, Neurophysiology, Neuroimmunology and Neuropharmacology, Instituto de Medicina Experimental, Universidad Central de Venezuela, Caracas, Venezuela
,
Bertha van der Dijs
1   Department of Physiological Sciences, Sections of Neurochemical, Neurophysiology, Neuroimmunology and Neuropharmacology, Instituto de Medicina Experimental, Universidad Central de Venezuela, Caracas, Venezuela
,
Beatriz Orozco
1   Department of Physiological Sciences, Sections of Neurochemical, Neurophysiology, Neuroimmunology and Neuropharmacology, Instituto de Medicina Experimental, Universidad Central de Venezuela, Caracas, Venezuela
,
Simon Rodriguez
1   Department of Physiological Sciences, Sections of Neurochemical, Neurophysiology, Neuroimmunology and Neuropharmacology, Instituto de Medicina Experimental, Universidad Central de Venezuela, Caracas, Venezuela
,
Scarlet Baez
1   Department of Physiological Sciences, Sections of Neurochemical, Neurophysiology, Neuroimmunology and Neuropharmacology, Instituto de Medicina Experimental, Universidad Central de Venezuela, Caracas, Venezuela
› Author Affiliations
Further Information

Correspondence to:

Fuad Lechin, MD, PhD.
Apartado 80.983
Caracas 1080-A
Venezuela
Phone: +58 212 961 1048   
Fax: +58 212 961 0172   

Publication History

Received 17 August 2004

Accepted after resubmission 05 October 2004

Publication Date:
15 December 2017 (online)

 
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  • References

  • 1 Hocking WG. Primary and secondary erythrocytosis. In Mazza JJ. Ed Manual of clinical hematology. NewYork: Lippincott Williams & Wilkins; 2002: 73-89.
    Google Scholar
  • 2 Lechin F, van der Dijs B, Orozco B. et al Neuropharmacological treatment of refractory idiopathic thrombocytopenic purpura: Roles of circulating catecholamines and serotonin. Thromb Haemost 2004; 91: 1254-6.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 3 Lechin F, van der Dijs B, Lechin ME. Neuroautonomic, neuroendocrine, neuroimmune interactions. In: Lechin F, van der Dijs B, Lechin ME (eds). Neurocircuitry and Neuroautonomic Disorders: Reviews and Strategies of Therapy. Basel: Karger 2002; 57-9.
    PubMedGoogle Scholar
  • 4 Lechin F, van der Dijs B, Orozco B. et al Plasma neurotransmitters, blood pressure and heart rate during supine-resting, orthostasis and moderate exercise conditions in major depressed patients. Biol Psychiat 1995; 38: 166-73.
    CrossrefPubMedGoogle Scholar
  • 5 Gobbi G, Mirandola P, Tazzari PL. et al Flow cytometry detection of serotonin content and release in resting and activated platelets. Br J Haematol 2003; 121: 892-6.
    CrossrefPubMedGoogle Scholar
  • 6 Dale GL, Friese P, Batar P. et al Stimulated platelets use serotonin to enhance their retention of procoagulant proteins on the cell surface. Nature 2002; 415: 175-9.
    CrossrefPubMedGoogle Scholar
  • 7 Dominguez V, Govezensky T, Gevorkian G. et al Low platelet counts do not cause bleeding in an experimental model of immune thrombocytopenic purpura in mice. Haematologica 2003; 88: 679-87.
    PubMedGoogle Scholar
  • 8 Lechin F, van der Dijs B. Platelet serotonin and thrombostasis. J Clin Invest 2004 0 http://www.jci.org Letters April 21.
    PubMedGoogle Scholar
  • 9 Lechin F, van der Dijs B. Platelet activation and catheter intracoronary brachytherapy. Heart online 2004 heart.bmjjournals.com Read eLetters July 1.
    PubMedGoogle Scholar
  • 10 Lechin F, van der Dijs B, Orozco B. et al Elective stenting, platelet serotonin and thrombotic events. Platelets 2004; 15: 462.
    CrossrefPubMedGoogle Scholar
  • 11 Lechin F, van der Dijs B. Platelet aggregation, platelet serotonin and pancreatitis. J Pancreas 2004; 5: 237-9.
    PubMedGoogle Scholar

Correspondence to:

Fuad Lechin, MD, PhD.
Apartado 80.983
Caracas 1080-A
Venezuela
Phone: +58 212 961 1048   
Fax: +58 212 961 0172   

  • References

  • 1 Hocking WG. Primary and secondary erythrocytosis. In Mazza JJ. Ed Manual of clinical hematology. NewYork: Lippincott Williams & Wilkins; 2002: 73-89.
    Google Scholar
  • 2 Lechin F, van der Dijs B, Orozco B. et al Neuropharmacological treatment of refractory idiopathic thrombocytopenic purpura: Roles of circulating catecholamines and serotonin. Thromb Haemost 2004; 91: 1254-6.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 3 Lechin F, van der Dijs B, Lechin ME. Neuroautonomic, neuroendocrine, neuroimmune interactions. In: Lechin F, van der Dijs B, Lechin ME (eds). Neurocircuitry and Neuroautonomic Disorders: Reviews and Strategies of Therapy. Basel: Karger 2002; 57-9.
    PubMedGoogle Scholar
  • 4 Lechin F, van der Dijs B, Orozco B. et al Plasma neurotransmitters, blood pressure and heart rate during supine-resting, orthostasis and moderate exercise conditions in major depressed patients. Biol Psychiat 1995; 38: 166-73.
    CrossrefPubMedGoogle Scholar
  • 5 Gobbi G, Mirandola P, Tazzari PL. et al Flow cytometry detection of serotonin content and release in resting and activated platelets. Br J Haematol 2003; 121: 892-6.
    CrossrefPubMedGoogle Scholar
  • 6 Dale GL, Friese P, Batar P. et al Stimulated platelets use serotonin to enhance their retention of procoagulant proteins on the cell surface. Nature 2002; 415: 175-9.
    CrossrefPubMedGoogle Scholar
  • 7 Dominguez V, Govezensky T, Gevorkian G. et al Low platelet counts do not cause bleeding in an experimental model of immune thrombocytopenic purpura in mice. Haematologica 2003; 88: 679-87.
    PubMedGoogle Scholar
  • 8 Lechin F, van der Dijs B. Platelet serotonin and thrombostasis. J Clin Invest 2004 0 http://www.jci.org Letters April 21.
    PubMedGoogle Scholar
  • 9 Lechin F, van der Dijs B. Platelet activation and catheter intracoronary brachytherapy. Heart online 2004 heart.bmjjournals.com Read eLetters July 1.
    PubMedGoogle Scholar
  • 10 Lechin F, van der Dijs B, Orozco B. et al Elective stenting, platelet serotonin and thrombotic events. Platelets 2004; 15: 462.
    CrossrefPubMedGoogle Scholar
  • 11 Lechin F, van der Dijs B. Platelet aggregation, platelet serotonin and pancreatitis. J Pancreas 2004; 5: 237-9.
    PubMedGoogle Scholar

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