Thromb Haemost 2001; 86(02): 723-724
DOI: 10.1055/s-0037-1616118
Letters to the Editor
Schattauer GmbH

High Prevalence of Factor V Leiden Mutation among Healthy Individuals and Patients with Deep Venous Thrombosis in Lebanon:

Is the Eastern Mediterranean Region the Area of Origin of this Mutation?
Ali Taher
1   Department of Internal Medicine
,
Ismail Khalil
2   Surgery. Faculty of Medicine, American University of Beirut, Beirut, Lebanon
,
Ali Shamseddine
1   Department of Internal Medicine
,
Fadi El-Ahdab
1   Department of Internal Medicine
,
Ali Bazarbachi
1   Department of Internal Medicine
› Author Affiliations
Further Information

Publication History

Received 06 February 2001

Accepted 17 March 2001

Publication Date:
12 December 2017 (online)

 

 
  • References

  • 1 Rees DC, Cose M, Clagg JB. World distribution of Factor V Leiden. Lancet 1995; 346: 1133-4.
  • 2 De Stefano V, Chiusolo P, Paciaroni K, Leone G. Epidemiology of Factor V Leiden: Clinical implications. Semin Thromb Hemost 1998; 24: 367-79.
  • 3 Ridken PM, Hennekens CH, Lindpaintner K, Stampfer MJ, Eisenberg PR, Miletich JP. Mutation in the gene coding for coagulation Factor V and the risk of myocardial infarction, stroke, and venous thrombosis in apparently healthy men. New Engl J of Med 1995; 332: 912-7.
  • 4 Griffin JH, Evatt BL, Wideman C, Fernandez JA. Anticoagulant Protein C Pathway defective in a majority of thrombophilic patients. Blood 1993; 82: 1989-93.
  • 5 Koster T, Rosendaal FR, de Ronde F, Briet E, Vandenbroucke JP, Bertina RM. Venous thrombosis due to poor response to activated Protein C: Leiden thrombophilia study. Lancet 1993; 342: 1503-6.
  • 6 Svensson PJ, Daglback B. Resistance to activated Protein C as a basis for venous thrombosis. N Engl J Med 1994; 330: 517-21.
  • 7 Irani-Hakime N, Tamim H, Kreidy R, Almawi WY. The prevalence of Factor V R506Q mutation-Leiden among apparently health Lebanese. Am J Hematol 2000; 65: 45-9.