Thromb Haemost 1999; 82(06): 1779-1780
DOI: 10.1055/s-0037-1614921
Letters to the Editor
Schattauer GmbH

Platelet Multimerin and Its Proteolytic Processing

C. P. M. Hayward
1   From the Departments of Pathology and Molecular Medicine, and Medicine, McMaster University, the Hamilton Health Sciences Corporation, and the Hamilton Regional Laboratory Medicine Program, Hamilton, Ontario, Canada
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This work was supported by a grant from the Medical Research Council of Canada and by a grant and Research Scholar Award from the Heart and Stroke Foundations of Ontario and Canada.
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Publikationsverlauf

Received 31. Dezember 1998

Accepted after resubmission 29. Juni 1999

Publikationsdatum:
10. Dezember 2017 (online)

 

 
  • References

  • 1 Polgár J, Magnenat E, Wells TNC, Clemetson KJ. Platelet glycoprotein Ia* is the processed form of multimerin – isolation and determination of N-terminal sequences of stored and released forms. Thromb Haemost 1998; 80: 645-8.
  • 2 Hayward CPM, Hassell J, Denomme G, Rachubinski R, Brown C, Kelton JG. The cDNA sequence of human endothelial cell multimerin: A unique protein with RGDS, coiled-coil, and EGF-like domains, and a carboxyl terminus similar to the globular domain of complement C1q and collagens type VIII and X. J Biol Chem 1995; 270: 18246-51.
  • 3 Hayward CPM, Smith JW, Horsewood P, Warkentin TE, Kelton JG. p-155, a multimeric platelet protein that is expressed on activated platelets. J Biol Chem 1991; 266: 7114-20.
  • 4 Hayward CPM, Warkentin TE, Horsewood P, Kelton JG. Multimerin: A series of large disulfide-linked multimeric proteins within platelets. Blood 1991; 77: 2556-60.
  • 5 Hayward CPM, Bainton DF, Podor TJ, Smith JW, Stead R, Horsewood P, Warkentin TE, Kelton JG. Multimerin is found in the α-granules of resting platelets and is synthesized by a megakaryocytic cell line. J Clin Invest 1993; 91: 2630-9.
  • 6 Hayward CPM, Cramer EM, Song Z, Zheng S, Fung R, Massé JM, Stead R, Podor TJ. Studies of multimerin in human endothelial cells. Blood 1998; 91: 1304-17.
  • 7 Hayward CPM, Song Z, Zheng S, Fung R, Pai M, Massé JM, Cramer EM. Multimerin processing by cells with and without pathways for regulated protein secretion. Blood 1999; 94: 1337-47.
  • 8 Hayward CPM. Multimerin: A bench to bedside chronology of a unique platelet and endothelial cell protein – from discovery to function to abnormalities in disease. Clin Invest Med 1997; 20: 176-87.