Download PDF
Thromb Haemost 2004; 92(05): 1147-1149
DOI: 10.1055/s-0037-1614292
Case Report
Schattauer GmbH

Familial pernicious anaemia with hyperhomocysteinaemia in recurrent early pregnancy loss

Jean-Louis Guéant
1   INSERM-0014, University Hospital of Nancy, Vandoeuvre-les-Nancy, France
,
Mirande Candito
2   Laboratory of Biochemistry, University Hospital of Nice, Nice, France
,
Emmanuel Andres
3   Department of Internal Medicine, University Hospital of Strasbourg, France
,
Emmanuel Van Obberghen
2   Laboratory of Biochemistry, University Hospital of Nice, Nice, France
,
Jean-Pierre Nicolas
1   INSERM-0014, University Hospital of Nancy, Vandoeuvre-les-Nancy, France
› Author Affiliations
Further Information

Publication History

Received 19 May 2004

Accepted after revision 03 September 2004

Publication Date:
14 December 2017 (online)

    Permissions and Reprints

 

 

  • References

  • 1 Bolander-Gouaille C. Focus on Homocysteine and the Vitamins involved in its metabolism. Spinger-Verlag; 2002
  • 2 Zetterberg H. Methylenetetrahydrofolate reductase and transcobalamin genetic polymorphisms in human spontaneous abortion: biological and clinical implications. Reprod Biol Endocrinol 2004; 17: 7-15.
    PubMedGoogle Scholar
  • 3 Wouters MG, Boers GH, Blom HJ. et al. Hyperhomocystenamia: a risk factor in women with unexplained recurrent pregnancy loss. Fertil Steril 1993; 60: 820-5.
    CrossrefPubMedGoogle Scholar
  • 4 Quere I, Mercier E, Bellet H. et al. Vitamin supplementation and early pregnancy outcome in women with recurrent early pregnancy loss and hyperhomocysteinemia. Fertil Steril 2001; 75: 823-5.
    CrossrefPubMedGoogle Scholar
  • 5 Bennett MB. Vitamin B12 deficiency, infertility and recurrent foetal losses. J Reprod Med 2001; 46: 209-12.
    PubMedGoogle Scholar
  • 6 Gris JC, Perneger TV, Quere I. et al. Antiphospholipid/antiprotein antibodies, hemostasis-related autoantibodies, and plasma homocysteine as risk factors for a first early pregnancy loss: a matched case-control study. Blood 2003; 102: 3504-13.
    CrossrefPubMedGoogle Scholar
  • 7 Nelen WL, Bulten J, Steegers EA. et al. Maternal homocysteine and chorionic vascularization in recurrent early pregnancy loss. Hum Reprod 2000; 15: 954-60.
    CrossrefPubMedGoogle Scholar
  • 8 Ray JG, Laskin CA. Folic acid and homocysteine metabolic defects and the risk of placental abruption, pre-eclampsia and spontaneous pregnancy loss: a systematic review. Placenta 1999; 20: 519-29.
    CrossrefPubMedGoogle Scholar
  • 9 Guéant JL, Namour F. Vitamin B12 : absorption, metabolism and deficiency. In: Encyclopedia of Gastroenterology. Elsevier; 2003: 619-24.
    Google Scholar
  • 10 Martinelli I, Taioli E, Cetin I. et al. Mutations in coagulation factors in women with unexplained late fetal loss. N Engl J Med 2000; 343: 1015-8.
    CrossrefPubMedGoogle Scholar
  • 11 Gordon MM, Brada N, Remacha A. et al. A genetic polymorphism in the coding region of the gastric factor gene (GIF) is associated with congenital intrinsic factor deficiency. Human Mutation 2004; 23: 85-91.
    CrossrefPubMedGoogle Scholar
  • 12 Dittmar M, Kahaly GJ. Polyglandular autoimmune syndromes: immunogenetics and longterm follow-up. J Clin Endocrinol Metab 2003; 88: 2983-92.
    CrossrefPubMedGoogle Scholar
  • 13 Candito M, Magnaldo S, Bayle J. et al. Clinical B12 deficiency in one case of recurrent spontaneous pregnancy loss. Clin Chem Lab Med 2003; 41: 1026-7.
    PubMedGoogle Scholar
  • 14 Namour F, Olivier J, Abdelmouttaleb I. et al. Transcobalamin codon 259 polymorphism in HT-29 and Caco-2 cells and in Caucasians: relation to transcobalamin and homocysteine concentration in blood. Blood 2001; 15: 1092-8.
    PubMedGoogle Scholar