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Thromb Haemost 2003; 89(01): 3-8
DOI: 10.1055/s-0037-1613535
Review Article
Schattauer GmbH

Intravascular tissue factor pathway – a model for rapid initiation of coagulation within the blood vessel

Bernd Engelmann
2   Vaskuläre Biologie und Hämostase, Institut für Klinische Chemie, Ludwig-Maximilians-Universität München, Munich, Germany
,
Thomas Luther
1   Institut für Pathologie, Technische Universität Dresden, Dresden, Germany
,
Ingrid Müller
2   Vaskuläre Biologie und Hämostase, Institut für Klinische Chemie, Ludwig-Maximilians-Universität München, Munich, Germany
› Author Affiliations Financial support The investigations in the author’s laboratory have been supported by grants from the Deutsche Forschungsgemeinschaft.
Further Information

Publication History

Received 25 October 2002

Accepted 04 November 2002

Publication Date:
09 December 2017 (online)

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Summary

The loss of blood through vessel wall ruptures is initially prevented by the rapid adhesion of platelets to the subendothelium, and the formation of a thrombus consisting of platelets and different types of leukocytes. Concomitantly, the coagulation process is thought to be activated by vascular wall tissue factor (TF). Here, a new model for the initiation of coagulation is presented, based on unexpected findings on the presence and functional activation of TF within the blood itself. TF was recently found to be stored in the α-granules of resting platelets under physiological conditions. Activation by collagen exposes TF on the platelet cell membrane and on platelet derived microvesicles. Adhesive interactions of the TF bearing platelets and microvesicles to neutrophils and monocytes support the functional activation of the blood based TF. The intravascular TF pathway is proposed to play a significant role during hemostasis by enabling the generation of fibrin at the site of the developing thrombus.

Keywords

P-selectin - PSGL-1 - circulating microvesicles - factor VIIa - factor Xa
 

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