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Synthesis 2019; 51(11): 2402-2408
DOI: 10.1055/s-0037-1612279
DOI: 10.1055/s-0037-1612279
paper
One-Pot Three-Component Synthesis of Pyrrolidin-2-ones via a Sequential Wittig/Nucleophilic Addition/Cyclization Reaction
We gratefully acknowledge financial support of this work by the National Natural Science Foundation of China (No. 21572075) and the 111 Project B17019.Further Information
Publication History
Received: 06 November 2018
Accepted after revision: 28 January 2019
Publication Date:
04 March 2019 (online)
![](https://www.thieme-connect.de/media/synthesis/201911/lookinside/thumbnails/ss-2018-h0742-op_10-1055_s-0037-1612279-1.jpg)
‡ These authors contributed equally to this work.
Abstract
A new efficient synthesis of pyrrolidin-2-ones via sequential Wittig reaction/nucleophilic addition/cyclization was developed. The Wittig reaction of the phosphoranes with isocyanates produced ketenimine intermediates that were then treated with primary amines to give amidines, which were treated with catalytic sodium alkoxide to give 2-imino-5-oxopyrrolidine-3-carboxylates in good yields.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1612279.
- Supporting Information
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