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Synthesis 2019; 51(17): 3250-3258
DOI: 10.1055/s-0037-1611830
DOI: 10.1055/s-0037-1611830
paper
Rhodium-Catalyzed Double Isocyanide Insertion via a Vinylcarbodiimide Intermediate for the Synthesis of 2H-Pyrrol-2-imines
This project is supported by the Inner Mongolia University (Enhancing Comprehensive Strength Foundation, Grant No. 10000-1601010981), and National Natural Science Foundation of China (Grants No. 21672256 and 21562032).Further Information
Publication History
Received: 29 March 2019
Accepted after revision: 24 April 2019
Publication Date:
21 May 2019 (online)
Abstract
2H-Pyrrol-2-imine is an important structural motif exhibiting in biologically active compounds and natural products. An efficient rhodium-catalyzed one-pot reaction of one vinyl azide with sequentially with two different isocyanides is reported, which offers an alternative facile access to 3-amino-5-aryl-2H-pyrrol-2-imines bearing various substitution on the nitrogens in good yields. An unstable vinylcarbodiimide is the key intermediate in this cascade reaction.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1611830.
- Supporting Information
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