Stereoselective Synthesis of α-Aryl Amino Acids
Asymmetric α-Arylation of Amino Acids.
14 December 2018 (online)
Key wordsarylation - quaternary amino acids - potassium bistrimethylsilylamide - stereoselectivity - aryl amino acids
Quaternary amino acids play an important role as modifiers of peptide conformation and bioactivity. The authors describe an α-arylation of enantiopure amino acid precursors to form quaternary centers.
This KHMDS-mediated α-arylation of enantiopure amino acid precursors proceeds smoothly to provide quaternary amino acids in high yields and without significant loss of stereochemical integrity.