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Synfacts 2019; 15(01): 0045
DOI: 10.1055/s-0037-1611386
DOI: 10.1055/s-0037-1611386
Metals in Synthesis
Enantioselective Palladium-Catalyzed Dearomative Heck Reaction
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
14. Dezember 2018 (online)
Significance
The authors report an enantioselective palladium-catalyzed dearomative Heck process, which affords a variety of spiroheterocycles and benzo-fused heterocycles in high yields and enantioselectivities.
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Comment
Various sets of conditions were developed, depending on the heterocyclic scaffold employed. A remarkable number of examples (88) were demonstrated, and the synthetic utility of the products was displayed by a series of derivatizations.
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