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Synfacts 2018; 14(12): 1257
DOI: 10.1055/s-0037-16110111
DOI: 10.1055/s-0037-16110111
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
Nickel-Catalyzed Enantioselective Hydroalkylation of 1,3-Dienes
Further Information
Publication History
Publication Date:
19 November 2018 (online)
Significance
Transition-metal-catalyzed asymmetric addition of enols or enolates to unsaturated hydrocarbons remains an unanswered challenge. The authors have developed a regio- and stereoselective hydroalkylation of 1,3-dienes by nickel catalysis.
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Comment
This catalytic reaction provides a wide range of γ,δ-unsaturated ketones or esters in good yields and with high enantioselectivities. One product was easily converted into the nonsteroidal anti-inflammatory drug (R)-flobufen, which also exhibits immunomodulatory properties.
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