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Synthesis 2019; 51(11): 2397-2401
DOI: 10.1055/s-0037-1610862
DOI: 10.1055/s-0037-1610862
paper
A Facile and Efficient Approach for the Synthesis of 3-Aryl-4-hydroxy-1,3-thiazolidin-2-ones
This project was supported by Natural Science Foundation of Zhejiang Province (Grant No. LY16H300001) to G. Zhang and National Natural Science Foundation of China (Grant No. 81673291 and 81473074) and Osteoporosis & Breast Cancer Research Center, U.S.A. to Y. Yu.Further Information
Publication History
Received: 04 November 2018
Accepted after revision: 01 February 2019
Publication Date:
01 April 2019 (online)
![](https://www.thieme-connect.de/media/synthesis/201911/lookinside/thumbnails/ss-2018-h0737-op_10-1055_s-0037-1610862-1.jpg)
§ Yue Zhu and Qilin Wang contributed equally to this work.
Abstract
A facile and efficient method for the synthesis of 3-aryl-4-hydroxy-1,3-thiazolidin-2-ones by the reaction of 1,4-dithiane-2,5-diol with acyl azides is reported. This reaction proceeded well at 80 °C to afford products in excellent yields for a wide range of substrates. A possible mechanism has been proposed.
Key words
3-aryl-4-hydroxy-1,3-thiazolidin-2-ones - 1,4-dithiane-2,5-diol - acyl azide - nucleophilic addition - facile synthesisSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1610862.
- Supporting Information
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