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Synthesis 2019; 51(17): 3287-3294
DOI: 10.1055/s-0037-1610711
DOI: 10.1055/s-0037-1610711
paper
Palladium-Catalyzed C12-Selective Direct Arylation of [1,2-c]Quinazolin-6(5H)-ones
We gratefully acknowledge the University of l’Aquila and the Sapienza, University of Rome, for financial support.Further Information
Publication History
Received: 05 March 2019
Accepted after revision: 13 April 2019
Publication Date:
07 May 2019 (online)
Abstract
A straightforward approach to the synthesis of the challenging 12-arylindolo[1,2-c]quinazolin-6(5H)-ones through the palladium-catalyzed direct arylation of N-benzyl and NH-free [1,2-c]quinazolin-6(5H)-ones with aryl halides is described.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1610711.
- Supporting Information
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For recent reviews on the C–H arylation of arenes, see: