Planta Med 2016; 82(S 01): S1-S381
DOI: 10.1055/s-0036-1596462
Abstracts
Georg Thieme Verlag KG Stuttgart · New York

Zebiriosides A-P, oleanane saponins isolated by LC-SPE-NMR hyphenation from the roots of Dendrobangia boliviana

Autoren

  • I Zebiri

    1   Institut de Chimie Moléculaire de Reims UMR 7312 CNRS, Université de Reims Champagne-Ardenne, BP 1039, 51687 REIMS Cedex, France

  • A Gratia

    1   Institut de Chimie Moléculaire de Reims UMR 7312 CNRS, Université de Reims Champagne-Ardenne, BP 1039, 51687 REIMS Cedex, France

  • M Haddad

    2   UMR 152 Pharma Dev, Université de Toulouse, IRD, UPS, France

  • L Duca

    3   Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), UMR CNRS 7369, Université de Reims Champagne-Ardenne, BP 1039, 51687 REIMS Cedex, France

  • B Cabanillas

    4   Instituto de Investigación de la Amazonía Peruana (IIAP), Iquitos-Quistococha, Perú

  • L Paloque

    5   CNRS, LCC (Laboratoire de Chimie de Coordination) UPR8241, 205 route de Narbonne, BP 44099, F-31077 Toulouse Cedex 4, France
    6   Université de Toulouse, UPS, INPT, F-31077 Toulouse Cedex 4, France

  • M Sauvain

    2   UMR 152 Pharma Dev, Université de Toulouse, IRD, UPS, France

  • E Rengifo

    4   Instituto de Investigación de la Amazonía Peruana (IIAP), Iquitos-Quistococha, Perú

  • L Voutquenne-Nazabadioko

    1   Institut de Chimie Moléculaire de Reims UMR 7312 CNRS, Université de Reims Champagne-Ardenne, BP 1039, 51687 REIMS Cedex, France
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
14. Dezember 2016 (online)

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A phytochemical study of the roots of Dendrobangia boliviana allowed the identification of twenty saponins, from which sixteen are new structures (Zebiriosides A-P). Fourteen saponins were isolated using classical chromatography techniques (silica gel and RP-18) and six minor saponins (four new and two known) were isolated and identified using hyphenated LC-SPE-NMR system. These saponins are glycosides of serjanic or phytolaccinic acids, whose structures were established on the basis of their spectral data, mainly HR-TOFESIMS, 1D-NMR (1H, 13C, DEPT) and 2D-NMR (1H-1H COSY, TOCSY, HSQC, HMBC, and ROESY), and by comparison with literature data. These compounds were evaluated for their cytotoxic, antileishmanial and hemolytic activities. No antileishmanial or hemolytic activities were revealed, but zebirioside C and zebirioside I showed cytotoxicity against fibroblasts with IC50 of 6.4 and 5.6µM, respectively.

Acknowledgements: Financial support by CNRS, Conseil Regional Champagne Ardenne, Conseil General de la Marne, Ministry of Higher Education and Research (MESR) and EU-programme FEDER to the PlAneT CPER project is gratefully acknowledged.

Keywords: Dendrobangia boliviana, triterpenoid saponins, LC-NMR.


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