A Novel 18F-Labeling Method for the Synthesis of [18F]-Piperidine-Containing Ligands as Potential PET Radiotracers for σ Receptors
Gerardo X. Ortiz Jr.
a
Department of Chemistry, Duke University, Durham, NC 27708, USA eMail: qiu.wang@duke.edu
,
Kantapat Chansaenpak
b
Department of Radiology, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599, USA eMail: zibo_li@med.unc.edu
c
National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Pathum Thani, 12120, Thailand
,
Mengzhe Wang
b
Department of Radiology, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599, USA eMail: zibo_li@med.unc.edu
,
Xiaofen Ma
b
Department of Radiology, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599, USA eMail: zibo_li@med.unc.edu
d
Department of Medical Imaging, Guangdong No. 2 Provincial People’s Hospital, Guangzhou City, Guangdong Province, P. R. of China
,
Hui Wang
b
Department of Radiology, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599, USA eMail: zibo_li@med.unc.edu
,
Zibo Li*
b
Department of Radiology, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599, USA eMail: zibo_li@med.unc.edu
a
Department of Chemistry, Duke University, Durham, NC 27708, USA eMail: qiu.wang@duke.edu
› InstitutsangabenWe acknowledge financial support to this project from Duke University, the Camille and Henry Dreyfus Foundation (QW), and the Department of Radiology and BRIC at UNC Chapel Hill.
Published as part of the Cluster Alkene Halofunctionalization
# These authors contributed equally to this work.
Abstract
We report a novel 18F-labeling method for the preparation of 18F-containing piperidine derivatives. This method is demonstrated on the design and synthesis of 18F-labeled potential PET radiotracers of σ receptors for initial biological evaluations.
1 Introduction
2 Design and Synthesis of Novel [19F]-3 and [19F]-3′
3 Radiosynthesis of Novel [18F]-3 and [18F]-3′
4 In vivo Uptake and Pharmacokinetics of [18F]-3 and [18F]-3′
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